Biological Activities of Substituted Benzimidazole Derivatives

Authors

  • Arpit Katiyar Sai Meer College of Pharmacy Chibramau Kannuj
  • Jyoti Rai Sai Meer College of Pharmacy, Chhibramau, Kannauj.
  • Sunita Gangwar Sai Meer College of Pharmacy, Chhibramau, Kannauj.
  • Anjan Kumar Mohanty Maharana Pratap College of Pharmacy, Kothi, Mandhana, Kanpur, Uttar Pradesh.
  • Abhinav Prasoon Mishra Pranveer Singh Institute of Technology, Kanpur.

Keywords:

Benzimidazole, Pharmacophore, Anti-viral, Anti-bacterial

Abstract

Benzimidazole could be a heterocyclic aromatic chemical compound. It’s one of the impotant pharmacophore having privileged structure in therapeutic and medicinal chemistry. It plays the most vital role with lots of helpful therapeutic activities such as: antiulcers, antihypertensives, analgesic, medication, anti-virals, antifungals, anticancers, and antihistaminics. The review of the literature shows that the benzimidazole
derivatives square measure effective compound and range of reviews on the market for organic chemistry and medical specialty studies conformed that their molecules square measure helpful against a good style of micro-organisms. Due to their importance, the strategies for its synthesis became attention of artificial Organic Chemists. Thus within the gift review we have a tendency to tried to compile the chemistry numerous by product of substituted benzimidazole further as various medical specialty activities.

References

1. A Chimrri; AD Sarro GD Sarro; G Giho; M Zappala. ‘Synthesis and anticonvulsant properties of 2, 3, 3a-4-tetrahydro-1-H pyrrolo (1,2-a) benzimidazol-1-one derivatives’, Farmaco, 2001, 56, 821-826.
2. A Gellis; H Kovacic; N Boufatah; P Vanelle. ‘Synthesis and cytotoxicity evaluation of some benzimidazole-4, 7-diones as bioreductive anticancer agents’, Eur J Med Chem 2008, 43, 1858-1864.
3. A Orjales; LA Cires; PL Tudanca; I Tapia; R Mosquera; L Labeaga. ‘Benzimidazole-2-carboxylic acid amides and esters: a new class of 5HT3 ligands’, Eur J Med Chem 1999, 34, 415-422.
4. AL Dutra; KL Arienti; DJ Buzard. ) ‘Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands’, Bioorg Med Chem Lett 2006, 16, 6043-6048.
5. Ansari, K.F., Lal, C, Synthesis, physicochemical properties and anti-microbial activity of some new benzi-midazole derivatives. Eur J Med Chem 2009, 44: 4028- 4033.
6. BB Kumar; PV Rao. ‘Synthesis and structural studies on transition metal complexes derived from 1-(2-thienyl)- 1-ethanole-1H-benzimidazole’, Asian J Chem 2006, 18, 3060-3064.
7. E Bespolov; VA Bomvrovskii; DY Fonskii. ‘Synthesis and Prostaglandin like activity of combined azacyclic prostaglandin analog based on benzimidazole and pyrrole’, J Pharm Chem 1998, 32, 649-651.
8. FP Alonso; H.J Cook. ‘Synthesis and invitro cysticidal activity of new benzimidazole derivatives’, Eur J Med Chem 2009, 44, 1794-1800.
9. GN Vezquez; MD Vilchis; LY Mulia; V Melendez; Gerena L; AH Compos; R Castillo; FH Luis ‘Synthesis and antiprotozoal activity of some 2-trifluoromethyl-1H benzimidazole bioisosteres’, Eur J Med Chem 2006, 41, 135-141.
10. Grocer, H., Kus, C., Boykin, D.W., Yildiz, S., Altanlar, N. Synthesis and Anti-fungal Properties of Some Benzimidazole Derivatives. Bioorg Med Chem 2002, 10:2589-2596.
11. HA Barker; RD Smyth; H Weissbach; JI Toohey; JN Ladd; BE Volcani. ‘’Isolation and Properties of Crystalline Cobamide Coenzymes Containing Benzimidazole or 5,6-Dimethylbenzimidazole”, J Biolog Chem 1960, 235 (2), 480–488.
12. HV Huynh; JHH Ho; TC Neo; LL Koh. “Solventcontrolled selective synthesis of a trans-configured benzimidazoline-2-ylidene palladium (II) complex and investigations of its Heck-type catalytic activity”, J Organometal Chem 2005, 690(16), 3854–3860.
13. J Camacho; A Barazarte; N Gamboa; J Rodrigues; R Rojas; A Vaisberg; R Gilman; J Charris. ‘Synthesis and biological evaluation of benzimidazole-5-carbohydrazide derivatives as antimalarial, cytotoxic and antitubercular agents’, Bioorg. Med. Chem., 2011, In Press, doi:10.1016/j.bmc.2011.01.050.
14. JB Bariwal; AK Shah; MK Kathiravan; RS Somani; JR Jagtap; KS Jai ‘Synthesis and antiulcer activity of novel pyrimidylthiomethyl and Pyrimidylsulfinylmethyl benzimidazoles as potential reversible proton pump inhibitors’, Ind J Pharm Ed Res 2008, 42, 225-231.
15. JB Hendrickson; MS Hussein. ‘Seeking the ideal dehydrating reagent’, J Org Chem 1987, 52, 4137-4139.
16. JS Shukla; S Saxena; R Rastogi. ‘Synthesis of some newer, 1-heterocyclic amino/iminomethyl-2-substituted benzimidazoles as a potent CNS, anticonvulsant and monoamine oxidase inhibitory agents’, Curr Sci 1982, 17, 820-822.
17. JT Leonard; L Jeyaseeli; M Kumar; R Sivakumar. ‘Synthesis, anti-inflammatory and antibacterial activities of 4-substituted phenyl benzimidazoles’, Asian J Chem 2006, 18, 1104-1106.
18. Kazimierczuk, Z., Upcroft, J.A., Upcroft, P., Gorska, A., Starosciak, B., Laudy, A. Synthesis and antiproto-zoal activity of some 2-(trifluoromethyl)-1H-benzimidazole bioisosteres. Acta Biochim Pol 2002, 49: 185- 195.
19. KF Ansari; C Lal. ‘Synthesis and evaluation of some new benzimidazole derivatives as potential antimicrobial agents’, Eur J Med Chem 2009, 44, 2294-2299.
20. MB Deshmukh; AW Suryavanshi; SA Deshmukh; SS Jagtap. ‘Microwave assisted synthesis of 2,3,4-trisubstituted 1,2- dihydropyrimido-[1,2-a]
benzimidazole ‘, Ind J Chem 2009, 86B, 302-305.
21. N Siddiqui; MS Alam. ‘Anticonvulsant and toxicity evaluation of newer 1-{(1-(2-substitutedbenzyl)-1Hbenzo [d] imidazol-2-yl) methyl}-3-arylthioureas’, Der Pharm Chemica 2010, 2(2), 163-171.
22. N Srinivasan; A Balaji; G Nagrajan; R Suthakaran; Y Kumar; D Jagdesh. ‘Synthesis and biological screening of some new 3 (2-methyl-1,2-dihydropyrimido[1,2-c] benzimidazole-1-thionyl)-6,8-dibromo-2-substituted - 3H-qunazolin-4-one’, Asian J Chem 2008, 20, 4934-
4936.
23. Patil, A., Ganguly, S., Surana, S. A systemic review of benzimidazole derivatives as an antiulcer agent. Rasayan Journal of Chemistry, 2008, 1(3): 447-460.
24. PS Solominova; VS Pilyugin; AA Pyurin. ‘Targated search for new anthelmentic among 5 (6-Aminophenylthio (oxy)-2-amino benzimidazole derivatives. Part- 1 quantative structure activity relationship’, J Pharm Chem 2004, 38, 425-430.
25. R Jackstell; A Frisch; M Beller; D Rottger; M Malaun; B Bildstein. “Efficient telomerization of 1,3-butadiene with alcohols in the presence of in situ generated palladium(0)carbene complexes”, J Molec Cat A Chemica 2002, 185(1-2), 105–112.
26. RL Shingalapur; KM Hosamani; RS Keri; MH Hugar. ‘Derivatives of benzimidazole pharmacophore:
Synthesis, anticonvulsant, antidiabetic and DNA cleavage studies’, Eur. J. Med. Chem., 2010, 45, 1753–
1759.
27. RV Devivar; E kawashima. ‘Benzimidazole ribonucleosides: design,synthesis, and antiviral activity of certain 2-(alkylthio)-and 2-(benzylthio)-5,6-dichlro-1- (d-ribofuranosyl)benzimidazoles’, J Med Chem 1994, 37, 2942-2949.
28. SM Sondhi S Singh; A Kumar; O Lozach; L Meijer. ‘Synthesis, anti-inflammatory, analgesic and kinase inhibition activity evaluation of benzimidazole derivatives’, Bioorg Med Chem 2006, 14, 3758-3765.
29. SM Sondhi; S Rajvanshi; M Johar; N Bharti; A Azam; AK Singh. ‘Anti-inflammatory, analgesic and antiamoebic activity evaluation of pyrimido [1,6-a] benzimidazole derivatives synthesized by the reaction of ketoisothiocyanates with mono and diamines’, Eur J Med Chem 2002, 37, 835-843.
30. T Tripathi; JP Mishra. ‘QSAR studies on 4, 5, 6, 7-tetrabromo-benzimidazole derivatives as inhibitors of protein kinase CK2’, Ind Drugs 2008, 45, 809-813.
31. Tuncbilek, M., Kiper T., Altanlar, N. Synthesis and in vitro anti-microbial activity of some novel substituted benzimidazole derivatives having potent activity against MRSA. Eur J Med Chem 2009, 44:1024–1033.
32. VA Anisimova; AA Spasov; VA XZ Guo; L Shi; R Wang; XX Liu; BG Li. ) ‘Synthesis and biological activity of
9-dialkylaminomethyl-2-oxy (dioxy) phenylimidazo [1,2-a] benzimidazole derivative’, J Pharm Chem 2006, 40, 521-529.
33. Z Kazimierczuk; M Andrzejewska; J Kaustova; V Klimesova. ‘Synthesis and antimycobacterial activity of 2-substituted halogeno- benzimidazoles’, Eur J Med Chem 2005, 40, 203-220.
34. ZA Alagoz; C Kus T Coban. ‘Synthesis and antioxidant properties of novel benzimidazoles containing
substituted indoles’, J Enz Inhib Med Chem 2004, 20, 325-331.

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Published

2018-10-27

How to Cite

Katiyar, A., Rai, J., Gangwar, S., Mohanty, A. K., & Mishra, A. P. (2018). Biological Activities of Substituted Benzimidazole Derivatives. Journal of Drug Discovery and Development ( ISSN:2581-6861), 2(1), 2-10. Retrieved from https://medicaljournalshouse.com/index.php/JDrug-Discovery-Development/article/view/58