The Ailments and Contraindications of Hyperthyroidism in Conceived Women - A Brief Review

Authors

  • Nikita Pal Department of Pharmacy Practice, NIMS Institute of Pharmacy, Rajasthan. https://orcid.org/0000-0003-2115-3332
  • Shambaditya Goswami Department of Pharmaceutical Chemistry, NIMS Institute of Pharmacy, Rajasthan.

Keywords:

Hyperthyroidism, Anti-Thyroid Drugs, Fetal Abnormality, Thyroid, Autoimmune Thyroid Disease, Congenital Anomalies, Grave’s Disease

Abstract

Hyperthyroidism or overactive thyroid is a medical condition where thyroid hormones produce excessively by thyroid gland. Hyperthyroidism and complications in pregnancy are correlated with each-other. Thyroid dysfunctions embroil pregnancy and make risk of maternal and fetal health. The list of complications during gestation period are premature delivery, pre-eclampsia, increased risk of habitual abortion, cardiac dysfunction, intrauterine fetal death, fetal congenital anomalies, fetal retardation, congenital hypothyroidism leading to increase the probability of maternal as well as perinatal morbidity and mortality. The present study represents a brief review on different complications and contraindications of hyperthyroidism during the gestation period of women and fetus. A web-based search viz. PUBMED, SPRINGER, ELSEVIER, GOOGLE scholar, RESEARCH GATE etc. and several research articles, review papers were used for making the review successful. The diagnosis of hyperthyroidism in conceived women is contraindicated due to the teratogenic effect of.123 Thyroid scanning. Pregnant women with Grave’s disease are at high risk of developing severe hyperthyroidism called as ‘Thyroid Storm’. Grave’s disease may be presented or initially
exacerbated during the first trimester of pregnancy. Anti-thyroid drugs are referred to the patients in this respect. If these drugs are unsuccessful, then surgery is an alternative option. Radioiodine is also contraindicated to treat hyperthyroidism during pregnancy because it crosses the placenta and shows teratogenicity in fetus.
If the treatment is given to such patients delicately and follow all the guidelines for managing hyperthyroidism in conceived women, then we will surely able to conquer this condition in further upcoming days.

How to cite this article: Pal N, Goswami S. The Ailments and Contraindications of Hyperthyroidism in Conceived Women - A Brief Review. Int J Adv Res Pharm Edu 2019; 1(1): 22-24.

References

Joseph DT, Robert TL, Gary YC et al. Pharmacotherapy: A pathophysiologic approach. 9th edition. McGraw-Hill Education, USA. 2014.

Brian WR, Nicki CR, Stuart R et al. Davidson’s principles and practice of medicine. 22nd edition. Elsevier 2014.

Erik AK, Elizabeth PN, Gregory BA et al. Guidelines of the American thyroid association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. American Thyroid Association. 2017; 27(3): 345-346.

Stine AL, Jorn O, Chun WS et al. Spontaneous abortion, stillbirth and hyperthyroidism: a Danish populationbased study. Eur Thyroid J 2014; 3(3): 164-172.

Phenelope SM, Alison N, Edward JA. Maternal thyroid disease and preterm birth: systematic review and meta-analysis. The journal of clinical endocrinology & metabolism 2015; 100(11): 4325-4331.

Ahmed RG. Maternal hyperthyroidism and pregnancy complications. Trends in technical & scientific research 2018; 1(3): 555-563.

Grigoriu C, Cezar C, Grigoras M et al. Management of hyperthyroidism in pregnancy. J Med Life 2008; 1(4): 390-396.

Delay F, Dochez V, Biquard F et al. Management of fetal goiter: 6 years retrospective observational study in prenatal diagnosis and treatment centers of the pays de loire perinatal network. J matern fetal neonatal med 2018; 1-191.

Pregnancy and thyroid disease. Available from URL: www.thyroid.org. 2019.

De Groot L, Abalovich M, Alexander EK et al. Management of thyroid dysfunction during pregnancy and postpartum: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2012; 97: 2543-2565.

Andersen SL, Olsen J, Wu CS et al. Birth defects after early pregnancy use of antithyroid drugs: a Danish nationwide study. J Clin Endocrinol Metab 2013; 98: 4373-4381.

Leung AM, Pearce EN, Braverman LE. Perchlorate, iodine and thyroid. Best Pract Res Clin Endocrinol Metab. 2010; 24: 133-141.

Diav-Citrin O, Shechtman S, Tahover E et al. Pregnancy outcome following in utero exposure to lithium: a prospective, comparative, observational study. Am J Psychiatry 2014; 171: 785-794.

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Published

2019-12-30