Antibacterial and Cytotoxic Properties of Terminalia chebula Fruits
Keywords:
Terminalia chebula, Antibacterial Properties, Anticancer PotentialAbstract
Terminalia chebula fruits are recognized for their potent antibacterial and cytotoxic properties, offering significant potential as sources of bioactive compounds for therapeutic use. These fruits exhibit robust antibacterial activity against a wide array of pathogenic bacteria, encompassing both Gram-positive and Gram-negative species. The efficacy is attributed to their rich composition of tannins, flavonoids, and phenolic acids, which disrupt bacterial cell walls, inhibit essential enzymes, and chelate vital metal ions crucial for bacterial growth. This multifaceted approach not only curtails bacterial proliferation but also mitigates the risk of antibiotic resistance development. Moreover, Terminalia chebula enhances the effectiveness of conventional antibiotics through synergistic interactions, promising more efficacious treatments for bacterial infections. On the cytotoxic front, Terminalia chebula demonstrates potent activity against diverse cancer cell lines, including those associated with breast, colon, and liver cancers. Mechanistically, the fruits induce apoptosis via caspase activation and mitochondrial pathways, facilitated by key compounds such as chebulagic acid, chebulinic acid, and ellagic acid.
How to cite this article:
Mukherji A, Gosh D. Antibacterial and Cytotoxic
Properties of Terminalia chebula Fruits. J Adv Res
Biochem Pharma 2024; 7(1): 1-5.
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