Designing Hypothesis of Quinoline Sulphonamide Hybrid as an Antimalarial Schizonticidal Blood Active Agent: Molecular Docking Approach
Keywords:Parasitic, Docking, Hybrid, Quinoline Sulphonamide
Malaria is deadly parasitic disease and approx 91% region of African countries are at risk of parasitic disease which lead to the 435000 deaths worldwide due to malaria. inspite of having several drugs for the treatment but the disease remains untreated due to the resistance caused in Plasmodium falciparum. Quinoline sulphonamide hybrid is a new approach to eradicate resistance. In the given study molecular docking study was performed using 30 quinoline sulphonamide hybrid analogues PDB code [4 RAN] Aza-acyclic nucleoside phosphonates. On the basis of moldock score molecular docking results revealed that compound number 9 is most active compound to the active site of protein with amino acid Gly169, Lys165, Val187. Docking studies of the compounds was done with the help of Molegro Virtual Docker software using docking method to study their activity.
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