Formulation and Evaluation of Hydrogel for the Treatment of Acne
Keywords:Acne, Hydrogel, Minocycline Hydrochloride, In-Vitro Drug Releasew
The aim of this work was to prepare and evaluate the topical hydrogel for the treatment of acne. Minocycline hydrochloride based hydrogel was prepared using the methyl cellulose gelling agent, the drug concentration was kept constant at 0.25%. The concentration of propylene glycol and methyl paraben was kept constant at 15% and 0.3%. The hydrogel formulation was evaluated for various physicochemical parameters like percentage drug content, spreadability and drug release. Formulation H9 was highest drug content 98.23±0.031% and drug released 90.96 ± 2.6% of the drug in 6hr. Out of these formulations H9 for hydrogel was selected to prepare final hydrogel formulation. Developed hydrogel (H9) were evaluated like drug content spredability, homogeneity, washability, pH etc. Developed hydrogel formulation can be better effect to treat acne due to high drug retention and permeation in skin layers.
How to cite this article:
Pandey PK et al. Formulation and Evaluation of Hydrogel for the Treatment of Acne. Int J Adv
Res Med Chem 2022; 4(1): 11-15.