(E)-4-benzamido-N’-(2,4-dinitrophenyl) benzohydrazonic acid: A Novel Molecule with Remarkable Bactericidal Activity against Both Gram-positive and Gram-negative Microbes
Keywords:
Benzamide, Benzohydrazonic acid, Escherichia coli, Staphylococcus aureus, Anti-microbial, Anti-bacterialAbstract
After knowing the multifarious potentials of benzamide compounds, a multi-aromatic compound was designed for overcoming the challenges imposed by the pathogens. The present investigation aimed at exploring the anti-bacterial perspectives of a rationally developed therapeutically privileged molecule 4-benzamido-N’-(2,4-dinitrophenyl)benzohydrazonic acid, produced through two-step chemical synthesis, against gram-negative microbial species (Escherichia coli) and grampositive microbial species (Staphylococcus aureus). The novel benzamidebased Schiff’s base compound expressed a fair anti-bacterial activity against anti-E. coli activity (ZOI = 17.4 mm, MIC = 500 ?g/mL), the Gram-negative strain and anti-S. aureus activity (ZOI = 19.6 mm, MIC = 500 ?g/mL), the Gram-positive strain as compared to ciprofloxacin (ZOI = 31.5 mm, MIC = 6.25 ?g/mL), the standard drug. However, the study opened new opportunities towards anti-microbial drug development by deeply focusing and exclusively highlighting the unexplored class of hybrid-benzamides or benzohydrazonic acids. More pre-clinical studies and investigations at various levels are essentially required as well as the establishment of structure-activity-relationship (SAR) of the whole series is needed which will open avenues for better pharmacotherapy against a large number of resistant pathogenic strains.
How to cite this article: Dhabarde DM, Kannake R, Kamble MA et al. (E)-4-benzamido-N’-(2,4-dinitrophenyl) benzohydrazonic acid: A Novel Molecule with Remarkable Bactericidal Activity against Both Gram-positive and Gram-negative Microbes. Int J Adv Res Med Chem 2020; 2(1): 1-4.
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