A Review on Natural Products as Drug Leads

Authors

  • Prachi Chaudhary Graduate student, ABESIT College of Pharmacy, Ghaziabad, Uttar Pradesh

Keywords:

Drug leads, natural products, biological activities, Drug discovery

Abstract

Natural products have been a rich source of inspiration and discovery for drug development over centuries. Their diverse chemical structures and biological activities have led to the identification of numerous successful drug leads across various therapeutic areas. This review paper provides an in-depth analysis of the significance of natural products as potential drugĀ  eads, discusses their advantages and challenges, explores modern approaches to natural product-based drug discovery, and concludes with insights into the future prospects of this field.

How to cite this article:
Chaudhary P, A Review on Natural Produts as
Drug Leads. Int J Adv Res Med Chem 2023; 5(1):
4-8.

References

Cordell GA. Sustainable sources of drugs from the biodiversity of medicinal plants. Fitoterapia 2011; 82(2): 61-71.

Newman DJ, Cragg GM. Natural products as sources of new drugs from 1981 to 2014. Journal of Natural Products 2016; 79(3): 629-661.

Butler MS. Natural products to drugs: natural productderived compounds in clinical trials. Natural Product Reports 2008; 25(3): 475-516.

Harvey AL, Edrada-Ebel R, Quinn, RJ. The re-emergence of natural products for drug discovery in the genomics era. Nature Reviews Drug Discovery 2015; 14(2): 111-129.

Koehn FE, C.arter GT. The evolving role of natural products in drug discovery. Nature Reviews Drug Discovery 2005; 4(3): 206-220.

Cragg GM, Newman DJ. Natural products: a continuing source of novel drug leads. Biochimica et Biophysica Acta (BBA)-General Subjects 2013; 1830(6): 3670-3695.

Butler MS, Cooper MA. Antibiotics in the clinical pipeline in 2017. The Journal of Antibiotics 2017; 70(1): 3-24.

Tan S. Y., Tang S. Y. Recent advances in marine algae polysaccharides: Isolation, structure, and activities. Marine Drugs 16(10): 362.

Atanasov, A. G., Waltenberger B, et.all. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnology Advances, 33(8): 1582-1614.

Koehn, F.E. High impact technologies for natural products screening. Progress in Drug Research, 65, 175-205.

Moellering, R.C,Cravatt, B.F. Functional lysine modification by an intrinsically reactive primary glycolytic metabolite. Science, 341(6145): 549-553.

Newman, D. J. Natural products as leads to potential drugs: an old process or the new hope for drug discovery?. Journal of Medicinal Chemistry 51(9): 2589-2599.

Patridge E, Gareiss P, Kinch, et.all An analysis of FDAapproved drugs: natural products and their derivatives. Drug Discovery Today 21(2): 204-207.

Xu, Y. J., Feng, et.all Natural product-derived drugs for the treatment of inflammatory bowel diseases. Frontiers in Pharmacology, 10, 1359.

Koehn, F. E. Naturwwal products as templates for the design of new drugs. Current Opinion in Chemical Biology 7(3): 355-363.

Kaur, R. Sharma, A.& Singh, Phytochemicals: natural modulators of aging. Aging and Disease 10(3): 524-551.

Capon, R. J, Rooney,et.all Microbial origin of sorbicillinoid biosynthesis in a community of Burkholderia symbionts isolated from Australian funnel-web spiders. Organic Letters 19(22): 6176-6179.

Kong, L. Y., Tan, et.all Microbial approaches in drug discovery and development. Progress in Drug Research, 60: 1-57

Downloads

Published

2023-07-10