Recent Progress in the Design and Development of Antibiotics: Combating Antimicrobial Resistance
The global rise of antimicrobial resistance (AMR) poses a grave threat to public health, necessitating urgent action to develop novel antibiotics. This review article provides a comprehensive overview of recent advancements in the design and development of antibiotics aimed at countering AMR. We explore innovative strategies, technologies, and promising antibiotic candidates that hold the potential to reshape the landscape of infectious disease treatment.
How to cite this article:
Ritika K, Recent Progress in the Design and Development of Antibiotics: Combating Antimicrobial Resistance . J Adv Res in medc che 2023; 5(1): 1-3.
Boucher, H. W., Talbot, et. al10 x ‘20 Progress— Development of new drugs active against Gram negative bacilli: an update from the Infectious Diseases Society of America. Clinical Infectious Diseases 2016; 56(12): 1685-1694.
Brown, E. D., & Wright, Antibacterial drug discovery in the resistance era. Nature 2011; 529(7586): 336-343.
Butler, M. S., & Cooper, Antibiotics in the clinical pipeline at the end of 2007; The Journal of Antibiotics,
Clatworthy, A. E., Pierson,Targeting virulence: a new paradigm for antimicrobial therapy. Nature Chemical Biology 2010; 3(9): 541-548.
Davies J., & Davies, D. Origins and evolution of antibiotic resistance. Microbiology and Molecular Biology Reviews 2017; 74(3): 417-433.
Hughes D., & Andersson, D. I Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms. Nature Reviews Genetics 2007 ;16(8) :459-471.
Payne, D. J, Gwynn, Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nature Reviews Drug Discovery 2011; 6(1): 29-40.
Silver, L. L. Challenges of antibacterial discovery. Clinical Microbiology Reviews 2013; 24(1): 71-109.
Spellberg B, Bartlett, J. G, The future of antibiotics and resistance. New England Journal of Medicine 2013; 368(4): 299-302.
Wright, G. D. Antibiotic adjuvants: rescuing antibiotics from resistance. Trends in Microbiology 2016; 24(11): 862-871.