Cellular Differentiation in Squamous Cell Carcinoma of Oral Cavity
Cellular Differentiation in Squamous Cell Carcinoma of Oral Cavity
Keywords:
oral carcinoma, squamous cell, carcinoma in situAbstract
Background: Oral cancer is ordinary cancer which includes the lips, buccal mucosa, gingiva, anterior, two-thirds of the tongue, the floor of the mouth and hard palate. The incidence of oral squamous cell carcinoma globally were approximately 354,864 new cases and 177, 384 deaths in 2018. Developing countries have the world’s highest reported incidence of oral cancer. The oral cancers incidence 90-95% of is squamous cell carcinoma in India.
Materials and Methods: All the cases of oral cancer, which were diagnosed in the department of pathology during the period of 1st January 2019 to July 2022, were registered for the study. There were 37 cases of oral squamous cell carcinoma of various grades and different morphology details. Wherever required, the paraffin blocks were studied. The 37 cases were grouped into four categories, Carcinoma in-Situ, Well differentiated, moderately differentiated, poorly differentiated.
Results: Out of 37 cases, there were four cases of carcinoma in situ, 16 cases of well-differentiated squamous cell carcinoma, 12 cases of moderately differentiated squamous cell carcinoma, and 5 cases of poorly differentiated squamous cell carcinoma. The mean age of Carcinoma in Situ was 49.5, well differentiated carcinoma was 46.56, moderately differentiated carcinoma was 44.00 and poorly differentiated was 53.00 years respectively. The mean age of buccal mucosa was 41.63 and mean age of tongue was 52.50 year. When the mean age of buccal mucosa was compared with tongue, the t value was 2.3739 however, those differences were not statistically significant (P=0.0232).
Conclusion: in the present study, high incidence of oral squamous cell carcinoma were seen in the 31-40 years age group. The incidence was high in male compared to females (M:F = 3.6:1). The 4 cellular differentiation was distinctly different from each other (coefficient of correlation = 0.01). The well-differentiated type 43.2% followed by moderately differentiated 38.2%, and then poorly differentiated 31.5% and least was carcinoma in situ 10.5%.
How to cite this article:
Kim W, Chauhan I, Agarwal R, Trisal M. Cellular Differentiation in Squamous Cell Carcinoma of Oral Cavity. Rec Adv Path Lab Med. 2020;6(1&2):16-20.
DOI: https://doi.org/10.24321/2454.8642.202009
References
Rivera C. Essentials of oral cancer. Int J Clin Exp Pathol. 2015 Sep;8(9):11884-94. [PubMed] [Google Scholar]
Lin NC, Hsien SI, Hsu JT, Chen MYC. Impact on patients with oral squamous cell carcinoma in different anatomical subsites: a single-center study in Taiwan. Sci Rep. 2021;11(1):15446. [PubMed] [Google Scholar]
Almangush A, Mäkitie AA, Triantafyllou A, de Bree R, Strojan P, Rinaldo A, Hernandez-Prera JC, Suárez C, Kowalski LP, Ferlito A, Leivo I. Staging and grading of oral squamous cell carcinoma: An update. Oral Oncol. 2020;107:104799. [PubMed] [Google Scholar]
Natarajan S, Mahajan S, Boaz K, George T. Morphometric analysis of nuclear features and volume-corrected mitotic index in the prognosis of oral squamous cell carcinoma. Oral Science International. 2009;6(2):85- 94. [Google Scholar]
Varshitha A. Prevalence of oral cancer in India. Journal of Pharmaceutical Sciences and Research. 2015;7(10): 845. [Google Scholar]
Dhanuthai K, Rojanawatsirivej S, Thosaporn W, Kintarak S, Subarnbhesaj A, Darling M, Kryshtalskyj E, Chiang CP, Shin HI, Choi SY, Lee SS, Aminishakib P. Oral cancer: A multicenter study. Med Oral Patol Oral Cir Bucal. 2018; 23(1):e23-9. [PubMed] [Google Scholar]
Mahmood N, Hanif M, Ahmed A, Jamal Q, Saqib, Khan A. Impact of age at diagnosis on clinicopathological outcomes of oral squamous cell carcinoma patients. Pak J Med Sci. 2018;34(3):595-9. [PubMed] [Google Scholar]
Coletta Ricardo D, Yeudall W. Andrew, Salo T. Grand challenges in oral cancers. Front Oral Health. 2020;1: 3. [PubMed] [Google Scholar]
Sharma P, Saxena S, Aggarwal P. Trends in the epidemiology of oral squamous cell carcinoma in western UP: an institutional study. Indian J Dent Res. 2010;21(3):316-9. [PubMed] [Google Scholar]
Rivera C, Venegas B. Histological and molecular aspects of oral squamous cell carcinoma (Review). Oncol Lett. 2014;8(1):7-11. [PubMed] [Google Scholar]
Paige AJ. Redefining tumour suppressor genes exceptions to the two-hit hypothesis. Cell Mol Life Sci. 2003;60(10):2147-63. [PubMed] [Google Scholar]
Rivera C, Venegas B. Histological and molecular aspects of oral squamous cell carcinoma (Review). Oncol Lett. 2014;8(1):7-11. [PubMed] [Google Scholar]
Almangush A, Mäkitie AA, Triantafyllou A, de Bree R, Strojan P, Rinaldo A, Hernandez-Prera JC, Suárez C, Kowalski LP, Ferlito A, Leivo I. Staging and grading of oral squamous cell carcinoma: An update. Oral Oncol. 2020;107:104799. [PubMed] [Google Scholar]
Stenman C, Gonzalez H, Gillstedt M, Dellgren G, Hasséus B, Holmberg E, Rexius H, Öhman J, Paoli J. Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients. Dermatol Pract Concept. 2018;8(4):330-6.
[PubMed] [Google Scholar]
Effiom OA, Adeyemo WL, Omitola OG, Ajayi OF, Emmanuel MM, Gbotolorun OM. Oral squamous cell carcinoma: a clinicopathologic review of 233 cases in Lagos, Nigeria. J Oral Maxillofac Surg. 2008;66(8): 1595-9. [PubMed] [Google Scholar]
Lin NC, Hsien SI, Hsu JT, Chen MYC. Impact on patients with oral squamous cell carcinoma in different anatomical subsites: a single-center study in Taiwan. Sci Rep. 2021;11(1):15446. [PubMed] [Google Scholar]
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