Recent Trends in Pharmaceutical Technology and Industries

Microarray-Based Biomarker Discovery

Deepti Tripathi — Sat, 30 Nov 2024 00:00:00 +0000

Microarray technology has revolutionized biomarker discovery by enabling the simultaneous analysis of thousands of genes across biological samples. The identification of differential gene expression patterns associated with disease states, the validation of candidate biomarkers through rigorous bioinformatics and statistical analyses, and their translation into clinical diagnostics and therapeutic interventions. The integration of microarray data with other omics technologies enhances the specificity and predictive power of biomarkers, facilitating precision medicine approaches tailored to individual patient profiles. Future directions focus on enhancing sensitivity, reproducibility, and clinical utility, thereby accelerating the discovery and implementation of robust biomarkers for improved patient outcomes.

How to cite this article:
Tripathi D. Microarray-Based Biomarker
Discovery. Rec Trends Pharm Tech Ind 2024
6(1): 17-21.

Emerging Technologies in Transdermal Drug Delivery

Tadesse Getu — Sat, 30 Nov 2024 00:00:00 +0000

Transdermal drug delivery (TDD) represents a promising alternative to traditional oral and injectable routes, offering non-invasive, controlled, and sustained administration of therapeutic agents. The various advanced TDD techniques, including microneedles, iontophoresis, sonophoresis, and nanotechnology-based systems, which address the inherent challenges of skin permeability and drug stability. Microneedles, including coated, dissolving, and hydrogel-forming types, enhance drug delivery through minimally invasive means, improving patient compliance. Iontophoresis utilizes mild electric currents to drive charged drug molecules across the skin, while sonophoresis employs ultrasound waves to increase skin permeability through mechanisms such as cavitation and thermal effects. Nanotechnology-based systems, including liposomes, solid lipid nanoparticles, nanoemulsions, polymeric nanoparticles, dendrimers, and nanocrystals, offer versatile platforms for enhanced drug solubility, stability, and targeted delivery.

How to cite this article:
Getu T. Emerging Technologies in Transdermal
Drug Delivery. Rec Trends Pharm Tech Ind 2024
6(1): 6-12.

Mucoadhesive Microspheres: Advances and Applications

Kanak Tripathi, Prashant Deshmukh, Nitish Goel — Sat, 30 Nov 2024 00:00:00 +0000

Mucoadhesive microspheres have emerged as a significant innovation in the field of drug delivery systems. By enhancing the bioavailability and controlled release of therapeutic agents, these microspheres offer a promising solution for targeting specific mucosal tissues. The development of efficient drug delivery systems has always been a crucial
aspect of pharmaceutical research. Among various delivery systems, mucoadhesive microspheres have gained considerable attention due to their ability to adhere to mucosal surfaces, thereby prolonging the residence time of the drug at the site of absorption. This review aims to provide a comprehensive overview of the principles, formulation
techniques, and applications of mucoadhesive microspheres.

How to cite this article:
Tripathi K , Deshmukh P , Goel N. Mucoadhesive
Microspheres: Advances and Applications. Rec
Trends Pharm Tech Ind 2024 6(1): 22-28.

Evaluation of the Ethanolic Leaf Extract of Tephrosia Villosa as an Anti-inflammatory Agent

Preveena Gautam, Swati Sharma — Sat, 30 Nov 2024 00:00:00 +0000

Tephrosia villosa, a member of the Fabaceae family, is a prominent plant in traditional medicine systems. The anti-inflammatory effects of its ethanolic leaf extract were investigated using a Carrageenan- induced inflammation model. In this study, inflammation was induced by subcutaneously injecting 0.1 ml of a freshly prepared 1% carrageenan
solution in 0.9% sodium chloride. The test drugs were administered orally at doses of 250 and 450 mg/kg one hour before the experiment began. The anti-inflammatory activity was measured by comparing the paw volume (in ml) of animals treated with the test drugs to those in the vehicle control group. Diclofenac sodium (25 mg/kg orally) served
as a reference drug. Results showed that the ethanolic leaf extract of T. villosa significantly reduced inflammation compared to the vehicle control. Diclofenac sodium also significantly reduced inflammation when compared to the control group. Among the two doses of T. villosa, the 450 mg/kg dose exhibited the most pronounced anti-inflammatory
effect. These findings suggest that T. villosa leaf extract has notable anti-inflammatory properties, with the higher dose proving to be more effective.

How to cite this article:
Gautam P , Sharma S. Evaluation of the Ethanolic

Leaf Extract of Tephrosia Villosa as an Anti-
inflammatory Agent. Rec Trends Pharm Tech

Ind 2024 6(1): 1-5.

Foam-Based Granulation in Pharmacy

Rajal Singh, Nidhi Mishra, Krushna Pandey — Sat, 30 Nov 2024 00:00:00 +0000

Foam-based granulation is an emerging technique in pharmaceutical manufacturing that offers several advantages over traditional wet granulation methods. This process involves the incorporation of foam, which acts as a binder to agglomerate powder particles into granules. The key benefits include reduced liquid consumption, improved homogeneity, and enhanced control over granule size and density. Additionally, foam-based granulation can lead to more efficient drying and reduced processing times. This method also presents an environmentally friendly alternative by minimizing solvent use and energy consumption. The present review delves into the mechanisms of foam-based granulation, its operational parameters, and its potential applications in the pharmaceutical industry. Through a comprehensive analysis of current research and practical case studies, we highlight the process’s efficiency, scalability, and impact on product quality. The findings suggest that foam-based granulation is a promising technology
that could revolutionize pharmaceutical granulation processes, making them more sustainable and cost-effective

How to cite this article:
Pandey K , Singh R , Mishra N. Foam-Based
Granulation in Pharmacy. Rec Trends Pharm
Tech Ind 2024 6(1): 13-16.