The Medicinal Plants and Diabetic Cardiomyopathy: A Recent Review


  • Aditya Prakash Department of Pharmacy Practice, NIMS Institute of Pharmacy, NIMS University, Jaipur, Rajasthan, India.
  • Ravindra Pal Singh Department of Pharmacy, NIMS Institute of Pharmacy, NIMS University, Jaipur, Rajasthan, India.
  • Subhanshi Gupta Department of Pharmacy Practice, NIMS Institute of Pharmacy, NIMS University, Jaipur, Rajasthan, India.


Background: Diabetic Cardiomyopathy (DbCM) is a definite primary disease operation, individualistic of CAD, which shows to heart-related diseases like heart failure in diabetic person. Cardiomyopathy is a structural and functional disease related to the dysfunctional of the heart muscles. Cardiomyopathies act as wide ranging group of disease that often causes to heart failure. In early age, cardiomyopathy is an asymptomatic and mostly symptoms are same as those seen in any type of heart failure. Symptoms are cough, shortness of breath, edema and nocturnal dyspnoea. Epidemiology and their clinical sequences have established a higher incidence of and ubiquity of heart failure in diabetes. Echocardiographic 7 magnetic resonance process has authorized a more precise means of phenotype diabetic cardiomyopathy. A modify in the metabolic process, diminished ca2+ homeostasis and production of energy, enhancing swelling and oxidative distress, also deposition of modern glycation end effect are method implications in the pathologic process of diabetic cardiomyopathy. Notwithstanding a growing delight in the pathophysiology of DbCM, there are no specified guidelines for recognizing patients or arranging a treatment program in clinical practice. Mainly anti-hyperglycaemic drugs are critical in the therapy of diabetic cardiomyopathy patients by effectively decreases, microvascular complication, suppress the effect of renal failure, retinopathy and nerve injury. Interestingly, many drugs presently in use can enhance cardiac efficiency and output beyond their capacity to control glycaemic. Methods: Biochemical data collections of plant parts were searched to the recognized key points about the medicines and their functions are critically introduced in this review. Results: In this evaluation, we will discuss the clinical also an experimental discussion of medicinal plants in the treatment of diabetic cardiomyopathy. Conclusion: Clinical trials are essentially required to demonstrate the effectiveness of presently available representative of HF also novel remedies in patients conspicuously with diabetic cardiomyopathy.

How to cite this article: Prakash A, Singh RP, Gupta S. The Medicinal Plants and Diabetic Cardiomyopathy: A Recent Review. Rec Trends Pharm Tech Ind 2021; 3(1): 1-6.


Patel DK, Kumar R, Prasad SK et al. Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus (Linn) F. Muell in streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed 2011; 1(4): 316-322.

Soumya D, Srilatha B. Late stage complications of diabetes and insulin resistance. J Diabetes Metab 2011; 2: 1000167.

Modak M, Dixit P, Londhe J et al. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr 2007; 40(3): 163. doi: 10.3164/jcbn.40.163.

Patel DK, Kumar R, Prasad SK et al. Pedalium murex Linn (Pedaliaceae) fruits: a comparative antioxidant activity of its different fractions. Asian Pac J Trop Biomed 2011; 1(5): 395-400.

Mukesh R, Namita P. Medicinal Plants with Antidiabetic Potential-A Review. American-Eurasian J Agric Environ Sci 2013; 13(1): 81-94.

Murea M, Ma L, Freedman BI. Genetic and environmental factors associated with type 2 diabetes and diabetic vascular complications. Rev Diabet Stud 2012; 9: 6-22. doi: 10.1900/RDS.2012.9.6.

Ponnusamy S, Ravindran R, Zinjarde S et al. Evaluation of traditional Indian antidiabetic medicinal plants for

human pancreatic amylase inhibitory effect in vitro. Evid Based Complement Alternat Med 2011; 2011: 515647.

Buowari O. Diabetes Mellitus-Insights and Perspectives. InTechOpen, Rijeka, Croatia, 2013.

Folorunso O, Oguntibeju O. Diabetes Mellitus-Insights and Perspectives. InTechOpen; Rijeka, Croatia: 2013. Chapter 5: The role of nutrition in the management of diabetes mellitus.

Saxena A, Vikram NK. Role of selected Indian plants in management of type 2 diabetes: a review. J Altern Complement Med 2004; 10(2): 369-378.

Lee HS. Rat lens aldose reductase inhibitory activities of Coptis japonica root-derived isoquinoline alkaloids. J Agric Food Chem 2002; 50(24): 7013-7026.

Rao MU, Sreenivasulu M, Chengaiah B et al. Herbal medicines for DM: A review. International journal of pharma Tech Research 2010; 2(3): 1883-1892.

Evans WC. Trease & Evans pharmacognosy, saunders company ltd. 2008; 13: 137.

WHO, Traditional medicine strategy, World Health Orgnisation, Geneva 2002.

Malviya N, Jain S, Malviya S. Antidiabetic potential of medicinal plants. Acta Pol Pharm 2010; 67(2): 113-118.

Hegazy GA, Alnoury AM, Gad HG. The role of Acacia Arabica extract as an antidiabetic, antihyperlipidemic, and antioxidant in streptozotocin-induced diabetic rats. Saudi medical journal 2013; 34(7): 727-33.

Gupta PD, De A. Diabetes Mellitus and its herbal treatment. International Journal of Research in Pharmaceutical and Biomedical Sciences 2012; 3(2):


Ayodhya S, Kusum S, Anjali S. Hypoglycaemic activity of different extracts of various herbal plants Singh. Int J Ayurveda Res Pharm 2010; 1(1): 212-224.

Kamalakkannan N, Prince PSM. Hypoglycaemic effect of water extracts of Aegle marmelos fruits in streptozotocin diabetic rats. Journal of ethnopharmacology 2003; 87(2): 207-10.

Bnouham M, Ziyyat A, Mekhfi H et al. Medicinal plants with potential antidiabetic activity-a review of ten years of herbal medicine research. Int J Diabetes Metab 2006; 14: 1-25.

Reaven E, Wright D, Mondon CE et al. Effect of ahe and diet of insulin secretion and insulin action in rats.Diabetes 1983; 32: 175-180.

Shukia R, Sharma SB, Puri D et al. Medicinal plants for treatment of diabetes mellitus. Indian journal of clinical biochemistry sciences 2000.

Eidi A, Eidi M, Esmaeili E. Antidiabetic effect of garlic (Allium sativum L.) normal and streptozotocin-induced diabetic rats. Phytomedicine 2006; 13(9): 624-9.

Kumar R, Sharma B, Tomar NR et al. Vivo evaluation of hypoglycemic activity of Aloe spp. And identification of its mode of action on GLUT-4 gene expression in vitro. Appl Biochem Biotechnol 2011; 164: 1246-1256.

Modak M, Dixit P, Londhe J et al. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr 2007; 40(3): 163-173.

Khosla P, Bhanwra S, Singh J et al. A study of hypoglycaemic effects of Azadirachta indica (Neem) in normal and alloxan diabetic rabbits. Indian J Physiol Pharmacol 2000; 44(1): 69-74.

Hashmat I, Azad H, Ahmed A. Neem (Azadirachta indica A. Juss)-A nature’s drugstore: an overview. Int Res J Biol Sci 2012; 1: 76-9.

Jayasree T, Chandrsekhar N, Rohit D. Evaluation of hypoglycemic effects of chloroform extracts of stem of Benincasa hispida in Male wistar rats. International journel of pharmaceutical & phytopharmacological research 2011; 1: 67-72.

Nazeerullah K, Sunil K, Pal SR et al. A pharmacognostic and pharmacological overview on Caesalpinia bonducella. Research Journal of Pharmaceutical, Biological and Chemical Sciences 2012; 3(1): 440-96.

Kannur D, Hukkeri V, Akki K. Antidiabetic activity of Caesalpinia bonducella seed extracts in rats. Fitoterapia 2006; 77(7): 546-9. doi: 10.1016/j.fitote.2006.06.013.

Sharma S, Dwivedi S, Swarup D. Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of Caesalpinia bonducella seeds in rats. Journal of Ethnopharmacology 1997; 58(1): 39-44.

Giribabu N, Karim K, Kilari EK et al. Phyllanthus niruri leaves aqueous extract improves kidney functions, ameliorates kidney oxidative stress, inflammation, fibrosis and apoptosis and enhances kidney cell proliferation in adult male rats with diabetes mellitus. J Ethnopharmacol 2017; 205: 123-137.

Ahangarpour A, Oroojan A. Effect of crust and seed hydro-alcoholic and aqueous extracts and pulp hydroalcoholic extract of Citrullus colocynthis on glucose, insulin and FIRI level in insulin resistant male rat’s. Horizon Med Sci 2013; 19(3): 149-54.