Exosomes as Drug Delivery Vehicles: Harnessing the Potential of Extracellular Vesicles
Abstract
Exosomes, small extracellular vesicles derived from various cell types, have emerged as promising candidates for drug delivery due to their unique biological properties. This review provides an in-depth analysis of the current state of research on exosomes as drug delivery vehicles, exploring their biogenesis, composition, and potential applications in therapeutic interventions. The focus is on harnessing the inherent advantages of exosomes, such as their natural targeting ability and low immunogenicity, to enhance drug delivery precision and efficacy.
How to cite this article:
Purnima TK, Reddy K. Exosomes as Drug Delivery
Vehicles: Harnessing the Potential of Extracellular
Vesicles. Rec Trends Pharm Tech Ind 2023; 5(2):
1-6.
References
Théry C, Zitvogel L, & Amigorena, S. (2002). Exosomes: composition, biogenesis and function. Nature Reviews Immunology, 2(8), 569-579.
Vader P, Mol EA, Pasterkamp G, Schiffelers RM. Extracellular vesicles for drug delivery. Advanced Drug Delivery Reviews 2016; 106: 148-156.
EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. (2013). Extracellular vesicles: biology and emerging therapeutic opportunities. Nature Reviews Drug Discovery, 12(5), 347-357.
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. (2011). Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nature Biotechnology, 29(4), 341-345.
Kamerkar, S., LeBleu, V. S., Sugimoto, H., Yang, S., Ruivo, C. F., Melo, S. A., ... & Kalluri, R. (2017). Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer. Nature, 546(7659), 498-503.
Lamichhane, T. N., Raiker, R. S., Jay, S. M. (2015). Exogenous DNA loading into extracellular vesicles via electroporation is size-dependent and enables limited gene delivery. Molecular Pharmaceutics, 12(10), 3650- 3657.
Lai, R. C., Arslan, F., Lee, M. M., Sze, N. S., Choo, A., Chen, T. S., ... & Lim, S. K. (2010). Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Research, 4(3), 214-222.
Tian, Y., Li, S., Song, J., Ji, T., Zhu, M., Anderson, G. J., & Nie, G. (2014). A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy. Biomaterials, 35(7), 2383- 2390.
Kim, M. S., Haney, M. J., Zhao, Y., Yuan, D., Deygen, I., Klyachko, N. L., & Batrakova, E. V. (2016). Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations. Nanomedicine: Nanotechnology, Biology and Medicine, 14(1), 195-204.
Jang, S. C., Kim, O. Y., Yoon, C. M., Choi, D. S., Roh, T. Y., Park, J., ... & Kim, Y. K. (2013). Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors. ACS Nano, 7(9), 7698-7710.
Yang, Y., Hong, Y., Nam, G. H., Chung, J. H., Koh, E., Kim, I. S. (2018). Virus-mimetic fusogenic exosomes for direct delivery of integral membrane proteins to target cell membranes. Advanced Materials, 30(40), 1804602.
Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., ... & Batrakova, E. V. (2015). Exosomes as drug delivery vehicles for Parkinson’s disease therapy. Journal of Controlled Release, 207, 18-30.
Alvarez-Erviti, L., Seow, Y. Q., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. (2011). Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nature Biotechnology, 29(4), 341.
Zhuang, X., Xiang, X., Grizzle, W., Sun, D., Zhang, S., Axtell, R. C., ... & Zhang, H. G. (2011). Treatment of brain inflammatory diseases by delivering exosome encapsulated anti inflammatory drugs from the nasal region to the brain. Molecular Therapy, 19(10), 1769-
Qi, H., Liu, C., Long, L., Ren, Y., Zhang, S., Chang, X., & Qian, X. (2016). Blood exosomes endowed with magnetic and targeting properties for cancer therapy. ACS Nano, 10(3), 3323-3333.
Li, J., Lee, Y., Johansson, H. J., Mäger, I., Vader, P., Nordin, J. Z., ... & Valadi, H. (2015). Serum-free culture alters the quantity and protein composition of neuroblastoma-derived extracellular vesicles. Journal of Extracellular Vesicles, 4(1), 26883.
Wahlgren, J., De L Karlson, T., Brisslert, M., Vaziri Sani, F., Telemo, E., & Sunnerhagen, P. (2012). Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes. Nucleic Acids Research, 40(17), e130.