Journal of Advanced Research in Pharmaceutical Sciences and Pharmacology Interventions
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Journal of Advanced Research in Pharmaceutical Sciences & Pharmacology Interventions is a Journal from bouquet of Advanced Research Publications. JoARPS is a Peer Review Journal and the published content is based on the original contributions in all fields of Pharmaceutical Sciences. The Journal publishes original research, review, short article, case studies, industrial research, editorials, book review. The Journal is published online quarterly and in print biannually. In addition to the regular issues, the Journal publishes selected proceedings and Special Issues for National and International Conferences but only as per the Focus and Scope of the selected Journals: Focus & Scope of Journal of Advanced Research in Pharmaceutical Sciences & Pharmacology Interventions: Pharmaceutics, Pharmacy Practice, Pharmaceutical Engineering, Pharmaceutical Technology, Pharmaceutical Analysis, Pharmaceutical Chemistry, Pharmaceutical Nanotechnology, Pharmaceutical Biotechnology, Pharmaceutical Microbiology, Pharmacology, Pharmacognosy, Pharmacoinformatics, Pharmacogenomics, Pharmacokinetics, Phytochemistry, Proteomics, Ayurvedic Medicine, Active Pharmaceutical Ingredients, Biopharmaceutics, Clinical and hospital pharmacy, Computational Chemistry, Genomics and Proteomics, Molecular drug design & drug developments, Natural products, Novel drug delivery systems, Synthetic chemistry, Validation Techniques, Pharmacodynamics, Pharmaceutical toxicology, Metabolic disposition of bioactive agents, Crystallization, lyophilization, chemical stability of drugs, Pharmacotherapy.Advanced Research Publicationsen-USJournal of Advanced Research in Pharmaceutical Sciences and Pharmacology InterventionsDesign, Optimization, and In-Vitro Evaluation of Ethyl Cellulose Nanosponge Gel for Enhanced Cutaneous Delivery of Itraconazole
https://medicaljournalshouse.com/index.php/PharmaceuticalSci-Pharmacology/article/view/1793
<p>Itraconazole (ITZ) is a potent BCS Class II triazole antifungal agent characterised by exceptionally low aqueous solubility, which limits its topical bioavailability and therapeutic efficacy. The present study aimed to design, optimise, and evaluate ethyl cellulose-based nanosponge hydrogels of itraconazole prepared via the emulsion solvent diffusion technique for enhanced controlled cutaneous release. Ten formulations (F1–F10) were prepared by varying drug-to-polymer and surfactant ratios. Particle size and polydispersity index (PDI) analysis revealed nanometric dimensions ranging from 205.6 nm to 882.7 nm. Scanning Electron Microscopy (SEM) confirmed the porous, spherical, and spongy morphology of the synthesised nanosponges. Formulation F6 exhibited the highest drug entrapment efficiency (70.6%) with an optimal particle size of 205.6 nm and PDI of 0.585. The optimised nanosponges were successfully incorporated into a Carbopol 934 hydrogel matrix containing permeation enhancers. In vitro release kinetics followed a zero-order transport mechanism with a high correlation coefficient (R² = 0.9958), fitting best into the Korsmeyer-Peppas model (n = 1.1581, indicating a Super Case II transport mechanism), achieving up to 88.6% cumulative drug release. The developed nanosponge gel system presents a promising platform for enhancing the solubility, stability, and controlled topical release of Itraconazole.</p> <p><strong>How to cite this article:</strong><br>Farheen F, Gour P. Design, Optimization, and In-Vitro Evaluation of Ethyl Cellulose Nanosponge Gel for Enhanced Cutaneous Delivery of Itraconazole. J Adv Res Pharm Sci Pharmacol Interv 2026; 9(2):1-4.</p>Fiza FarheenPriyanka Gour
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2026-08-252026-08-2592