TY - JOUR AU - Rathoure, Dr. Ashok K AU - Aggarwal, Savita Goyal PY - 2018/10/26 Y2 - 2026/09/07 TI - Manufacturing process with Chemical Reactions and mass Balance for 6 Pharmaceutical Drugs JF - Journal of Drug Discovery and Development ( ISSN:2581-6861) JA - JDDD VL - 1 IS - 1 SE - Articles DO - UR - https://medicaljournalshouse.com/index.php/JDrug-Discovery-Development/article/view/55 SP - 54-64 AB - Diclofenac is a non-steroidal anti-inflammatory drug. Bifonazole is a substituted imidazole antifungal agent structurally related to other drugs in this group. It possesses a broad spectrum of activity in vitro against dermatophytes, moulds, yeasts, dimorphic fungi and some Gram-positive bacteria. Aceclofenac is used to relieve pain in the conditions like osteoarthritis, rheumatoid Arthritis and ankylosing spondylitis. Clotrimazole is used to treat yeast infections of the vagina, mouth and skin such as athlete’s foot, jock itch and body ringworm. It can also be used to prevent oral thrush in certain patients. Dihydralazine sulfate is a vasodilator and an antihypertensive agent. It relaxes arterial smooth muscle by inhibiting the accumulation of intracellular free calcium. By relaxing vascular smooth muscle, vasodilators act to decrease peripheral resistance. Pyridoxine hydrochloride is the 4-methanol form of Vitamin B6 which is converted to Pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Here, we have presented the manufacturing process along with mass balance for 6 pharmaceutical drugs. ER -