Design and Analysis of Biodegradable Implant Rod for Application in Drug Delivery
Polymer implants are an exciting new development in the field of drug delivery systems. Because of their surface and bulk qualities, biodegradable polymers are often used. In the current investigation, a biodegradable implant in the form of a rod was manufactured by the use of a hot melt extrusion process, with PLGA and ethyl acetate serving as the plasticizer. Research was studied on the PLGA/EA rods' deterioration in vitro. At various time intervals, the rods' weight reductions were measured and studied. The techniques of DSC, TGA, and FTIR were used in order to characterize the rods. In order to determine the rod's capability for encapsulating drugs, a drug was first integrated into the rod. The amount of drug in rodents was determined by the use of the UV spectrophotometer method.
How to cite this article: Katyal P. Design and Analysis of Biodegradable Implant Rod for Application in Drug Delivery. J Durg Dis Dev 2022; 6(1): 19-28.
Uhrich, K.E.; Cannizzaro, S.M.; Langer, R.S.; Shakesheff, K.M. Polymeric systems for controlled drug release. Chem. Rev. 1999, 99, 3181-3198.
Nair, L.S.; Laurencin, C.T. Biodegradable polymers as biomaterials. Prog. Polym. Sci. 2007, 32, 762-798.
Hirenkumar K. Makadia and Steven J. Siegel ;Poly Lactic -co- Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier.
Rauwendaal CH. Polymer Extrusion, Hanser Publishers, München (1986) 20-25.
McGinity JW, Zhang F, Koleng J, Repka M. Hot-melt extrusion as a pharmaceutical process. Am Pharm Rev. 2001;4:25-37
Kefayat, A., & Vaezifar, S. (2019). Biodegradable PLGA implants containing doxorubicin-loaded chitosan nanoparticles for treatment of breast tumor-bearing mice.
K.A. Athanasiou, G.G. Niederauer, C.M. Agrawal Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers Biomaterials, 17 (1996), pp. 93-102
John C. M, Arthur J. T. Synthetic biodegradable polymers as orthopaedic devices. Biomaterials 2000; 21: 2335-2346.
Colomines G, Domenek S, Ducruet V, Guinault A. Influences of the crystallization rate on thermal and barrier properties of polylactide acid (PLA) food packaging films. Int J Mater Form 2008, Suppl 1: 607.
YucunZhu,Navnit H. Shah, VasimMalick, Martin H. Infeld, James W. McGinity.Solid-state plasticization of an acrylic polymer with chlorpheniraminemaleate and triethyl citrate.
Li SM, Garreau H, Vert M. Structure property relationships in the case of the degradation of massive aliphatic poly(alpha-hydroxy acids) in aqueous-media. J Mater Sci Mater Med 1990; 1(3):123-30.
Li SM, Garreau H, Vert M. Structure property relationships in the case of the degradation of massive poly(alpha-hydroxy acids) in aqueous-media. 3. Influence of the morphology of poly(L-lactic acid). J Mater Sci Mater Med 1990; 1(4): 198-206.
Omelczuk MO, McGinity JW. The influence of polymer glass-transition temperature and molecular-weight on drug release from tablets containing poly(DL-lactic acid). Pharm Res 1992; 9(1): 26-32.
Park TG. Degradation of poly(D,L-lactic acid) microspheres _ effect of molecular-weight. J Control Release 1994; 30(2): 161-73.
Reed AM, Gilding DK. Biodegradable polymers for use in surgery_poly(-glycolic)_poly(lactic acid) homo and co-polymers. 2. In vitro degradation. Polymer 1981; 22(4):494-8.
M. Mollan, “Historical overview,” in Pharmaceutical Extrusion Technology, I. Ghebre-Sellassie and C. Martin, Eds., pp. 1-18, CRC Press, New York, NY, USA, 2003.
A. Senouci, A. Smith, and P. Richmond, “Extrusion cooking,” Chemical Engineer, no. 417, pp. 30-33, 1985.
E. Sebestyen, “Problems of grains preservation in storage facilities,” Journal of Flour and Animal Feed Milling, vol. 10, pp. 24-25, 1974.
D. J. Wedlock and D. V. Wijngaarden, “Fast dispersing solid PVP-containing crop protection formulation and process therefore,” US Patent 1992, 5: 665, 369.
M. A. Repka, M. A. Elsohly, M. Munjal, and S. A. Ross, “Temperature stability and bioadhesive properties of 9-tetrahydrocannabinol incorporated hydroxypropylcellulose polymer matrix systems,” Drug Development and Industrial Pharmacy, vol. 32, no. 1, pp. 21-32, 2006.
How to Cite
Copyright (c) 2022 Journal of Drug Discovery and Development ( ISSN:2581-6861)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
We, the undersigned, give an undertaking to the following effect with regard to our article entitled
________________________________________________________________________________” submitted for publication in (Journal title)________________________________________________ _______________________________________________________Vol.________, Year _________:-
1. The article mentioned above has not been published or submitted to or accepted for publication in any form, in any other journal.
2. We also vouchsafe that the authorship of this article will not be contested by anyone whose name(s) is/are not listed by us here.
3. I/We declare that I/We contributed significantly towards the research study i.e., (a) conception, design and/or analysis and interpretation of data and to (b) drafting the article or revising it critically for important intellectual content and on (c) final approval of the version to be published.
4. I/We hereby acknowledge ADRs conflict of interest policy requirement to scrupulously avoid direct and indirect conflicts of interest and, accordingly, hereby agree to promptly inform the editor or editor's designee of any business, commercial, or other proprietary support, relationships, or interests that I/We may have which relate directly or indirectly to the subject of the work.
5. I/We also agree to the authorship of the article in the following sequence:-
Authors' Names (in sequence) Signature of Authors
1. _____________________________________ _____________________________________
2. _____________________________________ _____________________________________
3. _____________________________________ _____________________________________
4. _____________________________________ _____________________________________
5. _____________________________________ _____________________________________
6. _____________________________________ _____________________________________
7. _____________________________________ _____________________________________
8. _____________________________________ _____________________________________
(I). All the authors are required to sign independently in this form in the sequence given above. In case an author has left the institution/ country and whose whereabouts are not known, the senior author may sign on his/ her behalf taking the responsibility.
(ii). No addition/ deletion/ or any change in the sequence of the authorship will be permissible at a later stage, without valid reasons and permission of the Editor.
(iii). If the authorship is contested at any stage, the article will be either returned or will not be
processed for publication till the issue is solved.