An Analysis on the Impact of a Strawberry Fruits Hydroalcoholic Extract on Rats Suffering from Acute Pancreatitis
Abstract
The health advantages of strawberries have led to widespread consumption of the fruit all over the globe, worldwide in Western countries. The high necessary nutrient content, as well as the presence of vitamin C, both have relevant biological actions on the immune system that help to improve general human health. Antioxidant qualities of the fruit have been used to the treatment of several illnesses. The goal of the present study was to test the hypothesis that a fruit extract prepared using hydroalcoholic solvents may protect rats against acute pancreatitis brought on by L-arginine.
Male Sprague Dawley rats were randomly assignedto one of five groups:control, dis ease control, standard, treatment. The treatment groups received either 200 or 400 mg/ kg bw of the extracts orally over the group of seven days, while the control group received normal saline. L-arginine (200 mg/ 100g of dose weight) was given orally on day 5 of the study, this is what caused the pancreatitis. 72 hours following the onset of pancreatitis, the blood’s levels of the marker enzymes amylase, lipase, Superoxide dismutase (SOD), catalase, reduced glutathione were measured. After the animals had been put down, the pancreas was removed, histopathology and malonylaldehyde levels in the tissue were determined using an estimate method.
Amylase, lipase, MDA levels all significantly increased, whereas SOD, catalase, reduced glutathione levels decreased, according to the study’s findings. The findings were remarkably different from those from groups that administered extract, which revealed higher antioxidant levels and lower levels of amylase and lipase. There was a differentiation present that resembled the histology of the pancreatic tissue. Thus, administration of strawberry fruit extract showed a protective advantage against pancreatitis; however, more study is needed to pinpoint the exact molecular mechanism of action underlying this effect.
How to cite this article: Sahu L. An Analysis on the Impact of a Strawberry
Fruits Hydroalcoholic Extract on Rats Suffering from Acute Pancreatitis. J Durg Dis Dev 2022;
6(1): 1-7
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