Recent Advances in Pathology and Laboratory Medicine ( ISSN: 2454-8642 )

Platelet Indices: Indicators of Diabetes

2025-03-20T11:16:36+00:00

Aim and Objectives: The aim of this study is to study role of platelet
indices in with and without diabetes. The objectives included assessing
platelet count, mean platelet volume (MPV), platelet distribution
width (PDW), and platelet large cell ratio (P-LCR) within these patient
categories and to comparing platelet indices among healthy controls
and diabetic patients.
Materals and Methods: This prospective case-control study was
conducted at Departments of Pathology and Ophthalmology, School
of Medical Sciences & Research, Sharda Hospital, Greater Noida. Over
one and a half years, 100cases were enrolled, divided into 2 groups:
controls and Diabetics .The patients coming to ophthalmology opd for
retina checkup, their blood sample was taken. As same vial is used for
both estimation of platelet indices and HBA1C, both blood investigations
were noted. Inclusion criteria were adult patients with type 2 diabetes.
Exclusion criterion was anemia, certain eye conditions, uncontrolled
hypertension, cardiovascular issues, renal failure, anti-platelet drug
usage, malignancy, and type 1 diabetes were made.
Results: The results revealed significant variations among the groups.
In controls, the majority (90%) had MPV below 12, whereas in diabetic
patients most (58%) had MPV ranging from 12 to 15. PDW showed
similar trends, with 96% of controls having PDW below 17, while 96%
of diabetic patients was having as >20 . PLCR percentages ranged
within normal limits for controls but shifted towards higher values in
diabetic group. Platelet counts were consistent between control and
diabetic without Diabetes groups, averaging around 252,000 x10^3/
cumm, while diabetic patients had a slightly lower average count of
approximately 242,000 x10^3/cumm .
Conclusion: Thus we conclude that platelet indices are cost effective, easily
available, more reliant and more compliant tools which can indicate the
progression diabetes. MPV, PDW,PLCR and PLATELET COUNT, can play an
important role in Early detection , better diagnosis and prognosis of Diabetes.
Keywords: Mean Platelet Count, Platelet Distribution Width , Platelet
Large Cell Ratio, Diabete.
How to cite this article:
Mittal S, Dubey S, Goyal J L, Mishra J, Charu.
Platelet Indices: Indicators of Diabetes. Rec Adv
Path Lab Med. 2025;11(1&2):7-10.
DOI: https://doi.org/10.24321/2454.8642.202501

Targeting Cell Cycle Checkpoints and Apoptotic Resistance in Lung Adenocarcinoma: An In Silico Approach to Natural Compound Therapeutics

2025-04-07T06:47:48+00:00

Lung cancer remains a challenging because of its aggressive nature and limited treatment options. This study investigates the clinical significance of Chk1 and PARP1 overexpression in lung cancer and evaluated the potential natural compound as potential inhibitor. Bioinformatics analysis of TCGA data revealed significant upregulation of Chk1 and PARP1 in LUAD tissues compared to normal controls (p<0.05), high expression was found to be significantly correlated with poor overall survival. ADMET profiling was done to evaluate the pharmacological properties the compounds. Apigenin exhibited no Lipinski rule violations and was therefore selected for further studies. Molecular docking demonstrated strong binding of apigenin to both targets, with binding energies of -9.7 kcal/mol and -8.6 kcal/mol with Chk1 and PARP1 respectively, suggesting competitive inhibition at the ATP-binding and catalytic domains respectively. These computational findings align with existing experimental evidence of the ability of apigenin to induce G2/M arrest and sensitize cancer cells to DNA-damaging agents. This study proposes a novel therapeutic strategy combining apigenin with PARP inhibitors to obtain better patient outcomes in lung cancer cases by potentially overcoming chemoresistance. The findings of this study can further be validated by in vitro/ in vivo experiments to assess the efficacy of apigenin in modulating the Chk1/PARP1 pathways and improving treatment outcomes in lung cancer.

How to cite this article:
Rahman F, Ali S M, Dev K. Targeting Cell Cycle
Checkpoints and Apoptotic Resistance in Lung
Adenocarcinoma: An In Silico Approach to Natural
Compound Therapeutics. Rec Adv Path Lab Med.
2025;11(1&2):1-6.

DOI: https://doi.org/10.24321/2454.8642.202502

Health Consequences of Interpersonal Challenges

2025-04-10T09:50:19+00:00

Introduction: College students face a myriad of social challenges that significantly impact their mental and physical health. This comprehensive review explores the intricate relationship between social dynamics and health outcomes among college students. Key social challenges, including difficulties in making friends, roommate conflicts, and social pressures, are examined for their effects on mental health issues such as anxiety, depression, and stress. The review highlights how these mental health challenges can lead to physical health problems, including sleep disorders, substance abuse, and eating disorders. Additionally, the impact of social stressors on academic performance and cognitive function is discussed.

Methodology: This review article employs a comprehensive literature review methodology synthesizing findings from online sources published between 2019 and 2023. Key areas of focus include the prevalence of social challenges, their psychological and physiological impacts, and effective interventions.

Result: The results highlight the impact of social challenges in sowing the seeds of social anxiety leading to stress, depression along with other health problems and how important it is to address social issues in order to enhance students' general wellbeing. In order to mitigate these issues, effective interventions like peer support programs, mental health services, and faculty involvement are essential.

Conclusion: The review concludes with recommendations for enhancing campus health programs and policies to better support students. Future research directions are suggested to further understand the complex interplay between social dynamics and health in the college setting.

How to cite this article:
Singh M, Saini N. Health Consequences of
Interpersonal Challenges. Rec Adv Path Lab Med.
2025;11(1&2):15-18.

DOI: https://doi.org/10.24321/2454.8642.202503

Shift Work: Impact of Disrupted Circadian Rhythm on Health: A Review

2025-04-10T09:54:52+00:00

Introduction: Physical and mental health problems can arise from

disruptions in the circadian rhythm. The natural circadian cycle and

shift workers schedule frequently conflicts, which can lead to poor

sleep, exhaustion, mood swings, and a higher risk of developing chronic

illnesses like cancer, obesity, diabetes, and cardiovascular diseases. The

purpose of this review is to examine the complex connection between

shift employment and circadian rhythm disruption, as well as the ways

in which these disruptions lead to different health problems. In this

review we will ascertain the mediations that will hypothetically lessen

the negative health concerns linked to shift working, we will also look

at the principal mechanisms that explain these impacts.

Methodology: A systematic review of articles published in various

indexed medical journals, between 2014-2024 was taken. We highlighted

the impact of disturbed circadian rhythm on health which leads to

various life threatening diseases.

Result: Our observations specify that disrupted circadian rhythms

correlates with elevated blood pressure and 20% higher risk for

cardiovascular diseases. Shift workers reported a 50% higher incidence

of insomnia compared to day workers. There was reduced cognitive

performance during night shift due to misaligned circadian rhythms. Shift

workers exhibited 25% more workplace errors during night workers.

Discussion: Our conclusion emphasizes the growing burden of shift

work-related health issues, particularly as this type of work schedule

becomes prevalent in 24/7 economies. Implementation of forward-

rotating shift schedules and optimizing shift duration could reduce

circadian misalignment and improve work well-being.

How to cite this article:
Thappar H, Saini N. Shift Work: Impact of
Disrupted Circadian Rhythm on Health: A Review.
Rec Adv Path Lab Med. 2025;11(1&2):19-23.

DOI: https://doi.org/10.24321/2454.8642.202504

Robotic Assistance in Dental Procedures: Hype or Hope

2025-05-21T09:18:23+00:00

Robotic technology has revolutionized various fields of medicine,
offering enhanced precision, reduced invasiveness, and improved
outcomes. In dentistry, robotic assistance is an emerging innovation
with potential applications in implantology, endodontics, orthodontics,
maxillofacial surgery, and dental education. However, the integration
of robotics in dental practice raises important questions about clinical
efficacy, cost-effectiveness, accessibility, and the readiness of current
infrastructure.

How to cite this article:
Sharma A, Bnasal A, Saini N. Robotic Assistance
in Dental Procedures: Hype or Hope. Rec Adv
Path Lab Med. 2025;11(1&2):24-26.

DOI: https://doi.org/10.24321/2454.8642.202505