Evaluation of the Ethanolic Leaf Extract of Tephrosia Villosa as an Anti-inflammatory Agent
Keywords:
Tephrosia villosa, Anti-inflammatory, traditional medicineAbstract
Tephrosia villosa, a member of the Fabaceae family, is a prominent plant in traditional medicine systems. The anti-inflammatory effects of its ethanolic leaf extract were investigated using a Carrageenan- induced inflammation model. In this study, inflammation was induced by subcutaneously injecting 0.1 ml of a freshly prepared 1% carrageenan
solution in 0.9% sodium chloride. The test drugs were administered orally at doses of 250 and 450 mg/kg one hour before the experiment began. The anti-inflammatory activity was measured by comparing the paw volume (in ml) of animals treated with the test drugs to those in the vehicle control group. Diclofenac sodium (25 mg/kg orally) served
as a reference drug. Results showed that the ethanolic leaf extract of T. villosa significantly reduced inflammation compared to the vehicle control. Diclofenac sodium also significantly reduced inflammation when compared to the control group. Among the two doses of T. villosa, the 450 mg/kg dose exhibited the most pronounced anti-inflammatory
effect. These findings suggest that T. villosa leaf extract has notable anti-inflammatory properties, with the higher dose proving to be more effective.
How to cite this article:
Gautam P , Sharma S. Evaluation of the Ethanolic
Leaf Extract of Tephrosia Villosa as an Anti-
inflammatory Agent. Rec Trends Pharm Tech
Ind 2024 6(1): 1-5.
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