A Study of Antiobesity, Hypolipidemic and Anti-Atherogenic Activity of Poly Herbal Formulation against High Fat Diet-Induced Obesity in Albino Rats

Authors

  • Dr Amit Agrawal Bhabha Pharmacy Research Institute, Bhopal, Madhya Pradesh, India.
  • Rishikesh Sharma Bhabha Pharmacy Research Institute, Bhopal, Madhya Pradesh, India.

Keywords:

Antiobesity, Atherogenic Index, Curcuma Longa, Emblica Officinalis, Gymnema sylvestre, Hypolipidemic, Orlistat

Abstract

Obesity is one of the most common health problems and has become an epidemic on the global scale. Hyperlipidaemia is one of the greatest risk factors contributing to atherosclerosis and occurrence of coronary heart diseases from the first human civilization, research is going to find the drugs to treat obesity and its complications. Despite availability of many drugs in market to treat obesity, no single drug is ideal for treating all sorts of problems caused by obesity. So the research is going on finding perfect drug. In the present study was aimed to evaluate Antiobesity, Hypolipidemic and Anti-Atherogenic activity of polyherbal formulations fruit of Emblica officinalis, Rhizome of Curcuma Longa & Leaves of Gymnema sylvestre in high fat fed albino rats. Obesity was induced in wistar albino rats by feeding them with high fat diet for 25 days. Group-I served as normal control (1% Carboxy Methyl Cellulose (CMC)) and Group-II as obese control (1% CMC) fed on high fat diet, Group- III, IV were treated with various polyherbal formulations, Group-V served as positive standard (Orlistat 50 mg/kg body wt.). Hyperlipidaemia was induced by feeding animals with high fat diet per orally, consisting of coconut oil and Vanaspati ghee, daily ad libitum except normal control. The animals were treated for 14 days. At the end of the study, blood samples of the animals were sent for the estimation of the lipid profile and effects of test drug studied by comparing levels of the body weight, Total Cholesterol, Triglycerides, HDL, LDL, and Atherogenic index. The statistical significance between groups was analysed. There was a significant reduction in food intake, body weight, TC, TG, LDL and an increase in HDL levels in high fat diet fed rats treated Polyherbal formulation containing Emblica officinalis, Rhizome of Curcuma Longa & Leaves of Gymnema sylvestre as compared to the Positive Standard and Normal treated animals.

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Published

2019-05-28