Piperazine containing Murrayanine-Chalcones as Emerging Anti-microbial Agents
Keywords:
Murraya koenigii, Murrayanine, Chalcone, Piperazine, Antifungal, AntibacterialAbstract
Background: Murrayanine is an alkaloid of carbazole constitution obtained from curry tree Murraya koenigii L. It is the most active compound among the other 20 alkaloidal compounds in the plant and is highly explored till date. The semi-synthetic derivatives of murrayanine have been developed over the years which demonstrated drastically high activities than that of the parent compound.
Methodology: Piperazine containing chalcone molecule was developed rationally by Claisen-Schmidt reaction where the fusion of the two individual components; murrayanine, a natural product in the A-ring and piperazine containing acetophenone in the B-ring were performed, and screened carefully against virulent bacterial species; Staphylococcus aureus and Escherichia coli, and virulent fungal species; Aspergillus niger and Candida albicans.
Results: The molecule exhibited tremendous anti-bacterial activity against E. coli with ZOI of 24.39 mm and notable anti-fungal activity against C. albicans with ZOI of 22.93 mm. The activity against S. aureus was found to be 21.99 mm while fungicidal effect against A. niger was observed to be 20.07 mm.
Conclusion: The developed chalcone displayed remarkable anti-bacterial and anti-fungal activity. However, the activity was observed to be quite less than that of the standard anti-bacterial compound (ciprofloxacin) and standard anti-fungal compound (fluconazole).
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