The concept of abd?l-i-Adwiya (drug substitution/ therapeutic interchange) in Unani medicine – A critical appraisal

Authors

  • Athar Parvez Ansar Research Officer (U), Regional Research Institute of Unani Medicine, Srinagar, Jammu & Kashmir, India. https://orcid.org/0000-0002-5755-3525
  • Sumyyah Hasina Sana PG Scholar, Department of ‘Ilm al-Adwiya, Regional Research Institute of Unani Medicine, Srinagar, Jammu & Kashmir, India.
  • Huzaifa Ansari PG Scholar, Department of ‘Ilm al-Adwiya, Regional Research Institute of Unani Medicine, Srinagar, Jammu & Kashmir, India.

Abstract

Background:

The concept of drug substitution/ therapeutic interchange is an age old concept of Unani Medicine in which an appropriate substitute according to the principles is allowed, when the first desired drug is not available for treatment purposes. The present review has carried out to explore various drug substitutes mentioned in Unani literature to combat the present scenario where many Unani drugs have become endangered, over-exploited and costliest. Materials and Methods:

The classical Unani literature pertaining to drug substitution, ethnobotanical survey regarding phytochemistry and various scientific journals indexed in PubMed, Medline, Science Direct, SCOPUS, Google scholars and Research gate were analysed.

Results: This review study has shown that ancient to till date Unani physicians have given emphasis on need basis therapeutic interchange but the principles of drug substitution as discussed in Unani Medicine should strictly be followed to select an appropriate substitute. After reviewing classical Unani literature and scientific papers, it was also found that many substitutes of original drugs having similarities in pharmacological actions and phytoconstituents.

Conclusion: The effort should be made to investigate substitute of rare and high cost Unani drugs through preclinical, clinical and phytochemical studies by which this concept of Unani Medicine can be validated scientifically.

References

Rebelakou EP, Karamaou M, George A. The Impact of Ancient Greek Medicine in India: The birth of Unani Medicine. Acta Med Hist Adriat 2015; 13(2): 323-328.

Ansari AP, Ahmed ZN, Dar PA, Empirical evidence of animals used in biomedical research in Unani Medicine: An appraisal. International Journal of Unani and Integrative Medicine 2018; 2(4): 11-13.

Miraj S, Alesaeidi S, Kiani S. A systemic review of the relationship between dystemperament (sue mizaj) and treatments and management of diseases. (Ilaj and Eslah-e-Mizaj). Electronic Physician 2016; 8(12): 3378-3384.

Ansari AP, Ahmed ZN, Wadud A, et al. Ilaj bil Ghiza (Dietotherapy): A core mode of Unani treatment. Journal of Advanced Research in Pharmaceutical Sciences & Pharmacology Interventions 2018; 2(1): 27-35.

Parveen S, Wadud A, Makbul SAA, et al. Unani concept of drug substitution (therapeutic interchange) and its validation on scientific parameters. Journal of Ayurveda and Integrative Medicine 2019; doi: 10.1016/j.jaim.2017.11.006.

Azmi W. Kulyat-i-Advia. New Delhi: Idarah Kitab al-Shifa; 2017: 224.

Razi AMB. Kitab al-Abdal. Ed. 1st (English translation by CCRUM). New Delhi: Central Council for Research in Unani Medicine, Dept. of AYUSH, Ministry of H & FW, Govt. of India; 1999: 10, 11, 14, 35-36, 40, 44-45, 55, 58-59, 62, 64, 67, 68, 70-73, 75, 76, 77, 79, 82-83, 87, 91, 93.

Nagarajan M, Kuruvilla GR, Kumar KS, et al. Pharmacology of Ativisha, Musta and their substitutes. Journal of Ayurveda Integr Med 2015; 6(2):121-133.

Nagarajan M, Kuruvilla GR, Kumar KS, et al. Abhava pratinidhi dravya: A comparative phytochemistry of Ativisha, Musta and related species. Journal of Ayurveda Integr Med 2015; 6(1): 53-63.

Venkata Subramanian P, Kumar KS, Nair VS. Cyperus rotundus, a substitute for Aconitum heterophyllum: Studies on the Ayurvedic concept of Abhava pratinidhi dravya (drug substitution). Journal of Ayurveda Integr Med 2010; 1(1) 33-39.

Azmi SA. Abdal-i-Adwiya: Zarurat aur Ahmiyat. Jahan-e-Tib 2013; 14(4) 26-32.

Sina I. Al-Qanun fi’l Tibb. Book II (English translation by Dept. of Islamic studies) New Delhi: Jamia Hamdard; 1998: 85, 87, 91-2, 96, 99, 102-03, 107, 117, 120, 137, 141-3, 145, 149, 150-01, 158, 166, 168, 189, 202-05, 239, 240, 242-03, 245-06, 252-03, 258, 277, 282, 296, 298, 306, 320, 335, 337, 341, 360, 366, 377, 397, 401, 411, 418, 431, 450, 454, 468, 469, 473.

Betar I. Al Jame al-Mufradat al Aghzia wa al Adwiya. Ed. 1st. Vol. I. (Urdu translation by CCRUM). New Delhi: Central Council for Research in Unani Medicine, Dept. of AYUSH, Ministry of H & FW, Govt. of India; 1985: 6, 21, 51, 54, 71, 79, 82, 88, 97, 149-50, 179, 185, 187, 189-90, 197, 211, 215, 219, 233, 235, 237, 274-75, 277, 279, 285, 289, 297, 305, 316, 333, 341, 363, 388, 398, 401, 406, 427, 431, 437, 438, 441.

Betar I. Al Jame al-Mufradat al-Aghzia va al-Adwiya. Vol. II. (Urdu translation by CCRUM). New Delhi: Central Council for Research in Unani Medicine, Dept. of AYUSH, Ministry of H & FW, Govt. of India; YNM, 50, 65, 163, 173, 175, 177, 282, 323-24, 332-33, 335, 338, 342, 352.

Betar I. Al Jame al-Mufradat al-Aghzia va al-Adwiya. Vol. III. (Urdu translation by CCRUM). New Delhi: Central Council for Research in Unani Medicine, Dept. of AYUSH, Ministry of H & FW, Govt. of India; 1999: 110, 143, 248, 327.

Betar I. Al Jame al-Mufradat al-Aghzia va al-Advia. Vol. IV. (Urdu translation by CCRUM). New Delhi: Central Council for Research in Unani Medicine, Dept. of AYUSH, Ministry of H & FW, Govt. of India; 2003: 178, 196, 198, 200, 213, 254, 342, 400, 407, 412, 414, 445, 450.

Jurjani AH. Zakhira Khawarizm Shahi. Vol. 10th. (Urdu translation by Khan HH) New Delhi: Idarah Kitab al-Shifa; 2010: 157-59.

Hubal I. Kitab al-Mukhtarat fi al-Tib. Vol. 2nd. (Urdu translation by CCRUM). New Delhi: Central Council for Research in Unani Medicine, Dept. of AYUSH, Ministry of H & FW, Govt. of India; 2005: 50, 52, 55, 57, 60, 70, 74, 76, 77, 80, 85,92-95, 97, 100-05, 120, 122-4, 126, 134, 142, 151, 163, 165, 167-8, 171, 185, 194, 199, 204, 206, 209-10, 212, 221-22, 237, 244, 247, 277, 280, 282.

Al-Maghrabi AS. Kitab al-Fatah fi al-Altadawi Min Jamee Sabuf al-Amraz wa al-Shakawi. Ed. 1st. (Urdu translation by Bari A) Delhi: NCPC Printers; 2007: 44-236.

Ghani N. Khazain al-Advia. New Delhi: Idarah Kitab al-Shifa; YNM: 756-57.

Kabiruddin M. Makhzan al-Mufridat. Ed. 3rd. New Delhi: Idarah Kitab al-Shifa; 2014: 86, 90, 95, 97, 104, 107, 118, 123, 135, 156, 158, 165, 172, 252, 269, 361.

Parasuraman S, Thing GS, Dhanaraj SA. Polyherbal formulation: Concept of Ayuveda, Pharmacogn Rev 2014; 8(16): 73-80.

Evans WC. Trease and Evans Pharmacognosy. Ed. 16th. United Kingdom: Elsevier Limited; 2009: 3.

Wadud A. Ashrah al-Advia (Kulliyat-e-Advia). Burhan Pur: Printed by Mumtaz Screen Printer; 2004: 76-80.

Nagarajan M, Kuruvilla GR, Kumar KS, et al. Abhava pratinidhi dravya: A comparative phytochemistry of Ativisha, Musta and related species. Journal of Ayurveda and Integrative Medicine 2015; 6(1): 53-63.

Vaghela B, Soni H, Shukla H. A concept of herbal pratinidhi dravyas (substitute drugs) in Ayurved. Pharmagene 2013; 1(3): 85-88.

Khaire PA, Nandwate PB. Substitutes for Ayurvedic medicinal herbs: A review. International Journal of Recent and Futuristic Ayurveda Science 2017; 3: 107-114.

Ansari AP, Ahmed ZN, Wadud A, et.al. A concept of Muzir (Toxicity) and Musleh (Corrective) of Unani drugs with scientific evidences: An Overview. Journal of Research in Unani Medicine 2018; 7 (1): 70-77.

Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. Ed. 43rd. Pune: Nirali Prakashan; 2009: 4.11.

Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. Ed. 52nd. Pune: Nirali Prakashan; 2016: 4.11.

Pradeep KP. Controversy, adulteration and substitution- burning problems in Ayurveda practices. International Ayurvedic Medical Journal 2017: 2509-2514.

Qureshi EH. Muqadma-i-Ilmul Advia. New Delhi: Ejaz Publishing House; 1995: 122-132.

Qasmi SA, Qawaneen-i-Advia, Ed. 2nd. Aligarh: Aligarh Muslim University; 2015: 165-169.

Sastri JLN, Nesari TM, Rajendra H. Comparative study on the substitutes used in Ayurveda with special reference to substitutes for Pushkaramula (Inula racemosa Hook. F.) Viz. Kushta (Saussurea lappa Decne.) and Erandamulla (Ricinus communis L.): A clinical study. International Research Journal of Pharmacy 2013; 4(5): 92-100.

Venkatasubramanian P, Kumar KS, Nair VSN. Cyperus rotundus, a substitute for Aconitum heterophyllum: Studies on the Ayurvedic concept of Abhava pratinidhi dravya (drug substitution). Journal of Ayurveda and Integrative Medicine 2010; 1(1):33-39.

Giri CM. Concepts of Abhava Pratinidhi Dravyas- A rationale substitution of drugs- A Review. International Journal of Advanced Ayurveda, Yoga, Unani and Siddha and Homeopathy 2013; 2 (1):148-161.

Published

2020-07-18