Oral Cancer Causes and Prevention: An Overview

Authors

  • Shabir Ahmad Ganie Faculty of Pharmaceutical Sciences, Mewar University.
  • Neelam Somani Assistant Professor ,Faculty Of Pharmaceutical Sciences ,Mewar University
  • Parvaiz Ahmad Parry Faculty Of Pharmaceutical Sciences ,Mewar University
  • Aadil Mustafa Faculty Of Pharmaceutical Sciences ,Mewar University
  • Aadil Hussain Tantry Faculty Of Pharmaceutical Sciences, Mewar University

Keywords:

Oral cancer, Squamous cell carcinoma, Risk factors of oral cancer, Staging and treatment, Diagnosis

Abstract

Cancer is the unmanageable growth of cells that infect and have bad effect on the nearby tissue. Mouth cancer, or oral cancer, can occur anywhere in the mouth and is any cancerous tissue located in the oral cavity. Oral cancer (OC) is the commonest cancer in India. Oral mucositis (OM) is the oral materialization of mucosal injury (MUI), and is a common, bothersome, and treatment-interrupting toxicity of chemoradiation therapy for squamous cell cancers (SCC) of the head and neck. Medication errors with oral cancer therapies such as methotrexate and temozolomide have resulted in casualty. There are two different pathways through which people mainly acquire oral cancer. One is smoking or chewing tobacco and drinking alcoholic beverages and second is by exposure to the Human Papilloma Virus-16 (HPV-16). Out of total cases a little proportion of individuals (less than 7%) get affected by oral cancers, the cause of which is not known yet. It is currently believed that these are likely related to some genetic predisposition. Some people think this as an uncommon cancer, but it is increasing at an alarming rate every day.

References

1. Dolan RW, Vaughan CW, Fuleihan N. Symptoms in
early head and neck cancer: an inadequate indicator.
Otolaryngol Head Neck Surg 1998; 119(5): 463-67.
Pub Med Google Scholar.
2. Vernham GA, Crowther JA. Head and neck carcinoma
– stage at presentation. Clin Otolaryngol Allied Sci.
1994; 19(2): 120-24. PubMedGoogle Scholar.
3. Moore SR, Johnson NW, Pierce AM et al. The
epidemiology of mouth cancer: a review of global
incidence. Oral Dis 2000; 6: 65-74. [PubMed].
4. Sankaranarayanan R. Oral cancer in India: a clinical
and epidemiological review. Oral Surg Oral Med Oral
Pathol 1990; 69: 325-30. [PubMed].
5. Abbey LM, Kaugars GE, Gunsolley JC et al. Intraexaminer
and interexaminer reliability in the diagnosis of oral
epithelial dysplasia. Oral Surg Oral Med Oral Pathol
Oral Radiol Endod 1995; 80(2): 188-91.
6. Abbey LM, Kaugars GE, Gunsolley JC et al. The effect
of clinical information on the histopathologic diagnosis
of oral epithelial dysplasia. Oral Surg Oral Med Oral
Pathol Oral Radiol Endod 1998; 85(1): 74-77.
7. Chole RH, Patil RN, Basak A et al. Estimation of serum
malondialdehyde in oral cancer and precancer and its
association with healthy individuals, gender, alcohol,
and tobacco abuse. J Cancer Res Ther 2010; 6: 487-
91. [PubMed].
8. Zygogianni AG, Kyrgias G, Karakitsos P et al. Oral
squamous cell cancer: early detection and the role
of alcohol and smoking. Head Neck Oncol. 2011; 3: 2.
9. Ogden GR. Alcohol and oral cancer. Alcohol 2005; 35:
169-73.
10. Patel SG, Shah J. TNM staging of cancers of the head
and neck: Edge SB, Compton CC. The American Joint
Committee on Cancer: The 7th edition of the AJCC
cancer staging manual and the future of TNM. Ann
Surg Oncol 2010; 17: 1471-74.
11. GBD 2013 Mortality Causes of Death Collaborators
(2015). Global, regional, and national age-sex specific
all-cause and cause-specific mortality for 240 causes
of death, 1990–2013: a systematic analysis for the
Global Burden of Disease Study 2013; The Lancet 385
(9963): 117–71. doi:10.1016/S0140-6736(14)61682-2. PMC
4340604 PMID 25530442.
12. 13. Social inequalities in oral health: from evidence to
action (PDF). 2015. p. 9. ISBN 9780952737766.
14. Listl S, Jansen L, Stenzinger A et al. GEKID Cancer
Survival Working Group. 2013. Scheurer, Michael,ed. “Survival of Patients with Oral Cavity Cancer in
Germany”. PLoS ONE. 8 (1): e53415. doi:10.1371/journal.
pone.0053415. PMC 3548847. PMID 23349710.
15. Moore SR1, Johnson NW, Pierce AM, Wilson DF. “The
epidemiology of mouth cancer: a review of global
incidence”. 6 (2).
16. Neha, rita, arun; et al. (2016). “Changing Trends in
oral cancer - a global scenario” Cancer Facts & Figures
2017. America Cancer Society.
17. Krishna Rao SV, Mejia G, Roberts-Thomson K et al.
Epidemiology of oral cancer in Asia in the past decade-
-an update”. Asian Pacific journal of cancer prevention.
2013; 14(10): 5567-77.
18. Sok Ching Cheong, Patravoot Vatanasapt, Yang Yi-Hsin
et al. Oral cancer in South East Asia, Current status
and future directions. Transactional Research in Oral
Oncology 2017; 2: 1-9.
19. Al-Jaber A, Al-Nasser L, El-Metwally A. Epidemiology
of oral cancer in Arab countries. Saudi Medical Journal
2016; 37(3): 249–55.
20. All cancers (excluding non-melanoma skin cancer)
estimated incidence, mortality and prevalence
worldwide in 2012. International Agency for Research
on Cancer 2012.
21. Farah CS, Simanovic B, Dost F. Oral cancer in Australia
1982-2008: A growing need for opportunistic screening
and prevention. Australian Dental Journal 2014; 59(3).

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Published

2018-09-11