Potential Anti-pyretic Activity of Guiera senegalensis Leaves
Keywords:
G. senegalensis, Pyrexia, RatsAbstract
Introduction: Guiera senegalensis J. F. Gmel, known locally in Sudan as “Ghobeish” is a small herb, African species that is found mainly in West Africa. It has widespread uses in traditional medicine. In the current study, the putative anti-pyretic activity of the ethanolic extract of G. senegalensis leaves is assessed.
Methodology: 200 and 400 mg/kg body weight of G. senegalensis leaves extract were investigated on induced pyretic and non-pyretic rats. Pyrexia was induced in rats by sub-cutaneous injection of yeast solution. Temperature of rats was measured before and after treatment at 1, 2, 3, and 4 hours.
Results: 400 mg/kg body weight of G. senegalensis ethanolic extract administered to hyperthermic rats caused a significant (P?0.05) decrease in temperature after 1 hour of treatment when compared with the effect of standard group that was administered with paracetamol. 200 mg/kg of the extract has shown a decreasing effect on the temperature of the non-pyretic rats. Phytochemical screening of G. senegalensis leaves indicated the presence of large amounts of flavonoids and tannins, moderate amounts of steroids and cumarin, and little amounts of triterpenes.
Conclusion: From these findings, it is concluded that G. senegalensis ethanolic extract has evidence of reducing hyperthermia in experimental animals and this effect may be correlated to other biological activities of this medicinal plant.
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