Biofilms in Pharmaceutical Environments: Challenges and Strategies for Control

Authors

  • Akansha Mishra Department of pharmaceutical Science & Technology, AKS University, Satna.
  • Pragati Singh

Abstract

Biofilms, complex microbial communities embedded in extracellular polymeric substances, pose significant challenges in pharmaceutical environments. This review explores the formation, characteristics, and impact of biofilms in pharmaceutical manufacturing settings. It discusses the challenges associated with biofilm formation, the risks to product quality, and strategies employed for effective control. Understanding and addressing biofilm-related issues are crucial for maintaining the sterility and safety of pharmaceutical products.

How to cite this article:

Mishra A, Singh P. Biofilms in Pharmaceutical
Environments: Challenges and Strategies for
Control. J Durg Dis Dev 2023; 7(2): 1-6.

References

Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999). Bacterial biofilms: A common cause of persistent infections. Science, 284(5418), 1318-1322.

Donlan, R. M. (2002). Biofilms: Microbial life on surfaces. Emerging Infectious Diseases, 8(9), 881-890.

Bryers, J. D. (2008). Medical biofilms. Biotechnology and Bioengineering, 100(1), 1-18.

Mah, T. F., & O'Toole, G. A. (2001). Mechanisms of biofilm resistance to antimicrobial agents. Trends in Microbiology, 9(1), 34-39.

Stewart, P. S., & Costerton, J. W. (2001). Antibiotic resistance of bacteria in biofilms. The Lancet, 358(9276), 135-138.

Hall-Stoodley, L., Costerton, J. W., & Stoodley, P. (2004). Bacterial biofilms: From the natural environment to infectious diseases. Nature Reviews Microbiology, 2(2), 95-108.

Parsek, M. R., & Singh, P. K. (2003). Bacterial biofilms: An emerging link to disease pathogenesis. Annual Review of Microbiology, 57, 677-701.

Donlan, R. M., & Costerton, J. W. (2002). Biofilms: Survival mechanisms of clinically relevant microorganisms. Clinical Microbiology Reviews, 15(2), 167-193.

Ceri, H., Olson, M. E., Stremick, C., Read, R. R., Morck, D., & Buret, A. (1999). The Calgary Biofilm Device: New technology for rapid determination of antibiotic susceptibilities of bacterial biofilms. Journal of Clinical Microbiology, 37(6), 1771-1776.

Gristina, A. G., Hobgood, C. D., & Webb, L. X. (1987). Adherent bacterial colonization in the pathogenesis of osteomyelitis. Science, 237(4822), 57-60.

Percival, S. L., Knapp, J. S., & Wales, D. S. (2015). Biofilms and their potential in the food industry. In Biofilms in Infection Prevention and Control (pp. 329-361). Springer.

Chmielewski, R. A., & Frank, J. F. (2003). Biofilm formation and control in food processing facilities. Comprehensive Reviews in Food Science and Food Safety, 2(1), 22-32.

Azeredo, J., & Azevedo, N. F. (2014). Briquettin J (ed): The Role of Biofilms in the Biofilms—Science and Technology. InTech Open.

Mah, T. F., & O'Toole, G. A. (2001). Mechanisms of biofilm resistance to antimicrobial agents. Trends in Microbiology, 9(1), 34-39.

Drenkard, E., & Ausubel, F. M. (2002). Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation. Nature, 416(6882), 740-743.

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Published

2023-12-30

How to Cite

Mishra, A., & Singh, P. . (2023). Biofilms in Pharmaceutical Environments: Challenges and Strategies for Control. Journal of Drug Discovery and Development ( ISSN:2581-6861), 7(2). Retrieved from http://medicaljournalshouse.com/index.php/JDrug-Discovery-Development/article/view/1081