Polypharmacology Strategies in Breast Cancer Treatment

Abstract

Breast cancer is characterized by diverse molecular subtypes and intricate mechanisms of resistance, which pose formidable challenges to conventional single-target therapies. Polypharmacology represents a promising paradigm shift by simultaneously targeting multiple pathways and molecular targets implicated in tumor growth, metastasis, and treatment resistance. This multifaceted strategy not only enhances therapeutic efficacy but also addresses the dynamic interplay between cancer cells and their microenvironment. By integrating combinations of targeted therapies, immunomodulators, epigenetic modulators, and other agents, polypharmacology seeks to optimize treatment outcomes while mitigating the emergence of drug resistance—a pivotal obstacle in the long-term management of breast cancer.

How to cite this article:
Chakraborty D. Polypharmacology Strategies in
Breast Cancer Treatment. Int J Adv Res Pharm
Edu 2024; 6(1): 19-25.