Exploring the Molecular Mechanism of Phytoconstituents in Breast Cancer
Abstract
Cancer is a disease caused by many biological abnormalities that result in uncontrolled cell division. Breast cancer is considered the most prevalent cancer among women worldwide. A tumor in the chest, a change in breast size, discomfort in the breast, and fluid leakage from the nipple are all indicators of breast cancer. Cyclin-dependent kinases (CDKs) are commonly overexpressed, and the tumor suppressor protein p53 is under-expressed in breast cancer tissues. In addition, many cell cycle control proteins, including the cyclin-dependent kinases inhibitors, p27, p21, and p57 are downregulated simultaneously. Using natural compounds to target these molecules may provide valuable treatment for breast cancer as natural compounds have a great potential for advancement and cause fewer side effects. Since ancient times, people have used plants as a source of medicine since they are so abundant. Many medications used to treat human illnesses today are derived from plants. Testing natural extracts for potential anti-cancer biological activity is the first step in developing an effective and side-effect-free anti-cancerous therapy based on phytochemicals. Using natural compounds and their derivatives as anti-cancer agents offers a potential source for novel cancer treatments.
How to cite this article:
Annu, Kaur S, Sadaf, Shingatgeri VMM, Najm MZ. Exploring the Molecular Mechanism of Phytoconstituents in Breast Cancer. Rec Adv Path Lab Med. 2021;7(3&4):13-18.
DOI: https://doi.org/10.24321/2454.8642.202107
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