USG-Guided FNAC of Pediatric Lesions: An Experience and Retrospective Analysis of Two Teaching Hospitals
Keywords:
USG, FNA, Pediatric, ExperienceAbstract
Introduction: Accuracy of the FNAC results depends upon the amount and adequacy of the aspirated material from the lesion with proper staining and interpretation. Guided aspirate yields better diagnostic material from deep-seated and inaccessible lesion in comparison to routine FNA procedure. Aim: To present an experience of 30 cases of USG-guided FNAC in the pediatric population. Material and Methods: The study is a retrospective data analysis and included 30 pediatric cases of 0-18 years who were advised image-guided FNAC for various clinical diagnosis. Corresponding slides of the cases were examined from the archives of the Department of Pathology SSPHPGTI, Noida, U.P. and Era’s Lucknow Medical University, Lucknow, U.P. India. The variables were tabulated under the headings of demographic data, site of lesion and as per diagnosis as non-neoplastic or neoplastic. Nonneoplastic lesions were further classified into infective, inflammatory/ autoimmune, while neoplastic lesion as benign and malignant tumor. Data was analyzed as per statistical parameter and results were compiled and analyzed. Result: Out of 30 cases, 16 were females and 14 males with majority of males in the age group of 0 to 10 years and majority of the females in the age group of 11 to 18 years. The most common site to undergo FNAC in our study was abdominal swellings [mesenteric lymph nodes (10) followed by kidney mass (2) and ovarian mass (2)]. Only 3 cases were categorized as malignant lesions, the rest were benign. Infective lesion was the most common category with maximum cases reported as Koch’s abdomen (7). Three cases were noncontributory with no adequate yield. Conclusion: The study is an attempt to highlight our experience of USGguided FNAC diagnosis in pediatric population.
How to cite this article: Nath D, Tiwari N, Madan J, Singh S, Gupta P, Lal N et al. USG-Guided FNAC of Pediatric Lesions: An Experience and Retrospective Analysis of Two Teaching Hospitals. Rec Adv Path Lab Med 2019; 5(4): 23-27.
DOI: https://doi.org/10.24321/2454.8642.201923
References
Yang SI, Park KK, Kim JH. Thyroid metastasis from breast carcinoma accompanied by papillary thyroid carcinoma. Case Rep Oncol 2014; 7(2): 528-533. Available from: https://www.karger.com/Article/Abstract/365748 [DOI: 10.1159/000365748/ PubMed/ Google Scholar].
Wang JT, Huang R, Kuang AR. Comparison of presentation and clinical outcome between children and young adults with differentiated thyroid cancer. Asian Pac J Cancer Prev 2014; 15(17): 72717275. Available from: http://journal.waocp.org/ article_29758_8903cad720fdd3ce1dd7e0d696c38fd8. pdf [DOI: 10.7314/APJCP.2014.15.17.7271/ PubMed/ Google Scholar].
Chindris AM, Diehl NN, Crook JE, Fatourechi V, Smallridge RC. Undetectable sensitive serum thyroglobulin (<0.1ng/ml) in 163 patients with follicular cell-derived thyroid cancer: results of rhTSH stimulation and neck ultrasonography and long-term biochemical and clinical follow-up. J Clin Endocrinol Metab 2012; 97(8): 2714- 2723. Available from: https://academic.oup.com/jcem/ article/97/8/2714/2823315 [DOI: 10.1210/jc.20113017/ PubMed/ Google Scholar].
Cappelli C, Pirola I, De Martino E, Gandossi E, Cimino E, Samoni F et al. Thyroglobulin measurement in fine-needle aspiration biopsy of metastatic lymph nodes after rhTSH stimulation. Head Neck 2013; 35(1): E21-E23. Available from: https://onlinelibrary.wiley. com/doi/abs/10.1002/hed.21796 [DOI: 10.1002/ hed.21796/ PubMed/ Google Scholar].
Uruno T, Miyauchi A, Shimizu K, Tomoda C, Takamura Y, Ito Y et al. Usefulness of thyoglobulin measurement in fine-needle aspiration biopsy specimens for diagnosing cervical lymph node metastasis in patients with papillary thyroid cancer. World J Surg 2005; 29(4): 483-485. Available from: https://link.springer.com/ article/10.1007%2Fs00268-004-7701-0 [DOI: 10.1007/ s00268-004-7701-0/ PubMed/ Google Scholar].
Cunha N, Rodrigues F, Curado F, Ilhéu O, Cruz C, Naidenov P et al. Thyroglobulin detection in fine-needle aspirates of cervical lymph nodes: a technique for the diagnosis of metastatic differentiated thyroid cancer. Eur J Endocrinol 2007; 157(1): 101-107. Available from: https://eje.bioscientifica.com/view/journals/ eje/157/1/1570101.xml [DOI: 10.1530/ EJE-07-0088/ PubMed/ Google Scholar].
Giovanella L, Ceriani L, Suriano S. Lymph node thyroglobulin measurement in diagnosis of neck metastases of differentiated thyroid carcinoma. J Thyroid Res 2011; 2011: 621839. Available from: https:// www.hindawi.com/journals/jtr/2011/621839/ [DOI: 10.4061/2011/621839/ PubMed/ Google Scholar].
Agrawal P, Gupta A. Role of image Guided Fine Needle Aspiration Cytology in Diagnosis of Retroperitoneal Lesions in Pediatric Population. Journal of Evolution of Medical and Dental Sciences 2014; 3(72): 1529015296. Available from: https://pdfs.semanticscholar. org/1dcd/d8509afdbb80e7191751d33afefc2fd34c95. pdf [DOI: 10.14260/jemds/2014/4057/ ResearchGate/ Google Scholar].
Sohn YM, Kim MJ, Kim EK, Kwak JY. Diagnostic performance of thyroglobulin value in indeterminate range in fine needle aspiration washout fluid from lymph nodes of thyroid cancer. Yonsei Med J 2012; 53(1): 126-131. Available from: https://synapse. koreamed.org/search.php?where=aview&id=10.3349/ ymj.2012.53.1.126&code=0069YMJ&vmode=FULL [DOI: 10.3349/ymj.2012.53.1.126/ PubMed/ Google Scholar].
Mangla G, Arora VK, Singh N. Clinical audit of ultrasound guided fine needle aspiration in a general cytopathology service. J Cytol 2015; 32(1): 6-11. Available from: http:// www.jcytol.org/article.asp?issn=0970-9371;year=201 5;volume=32;issue=1;spage=6;epage=11;aulast=Man gla [PubMed/ Google Scholar].
Szakáll S Jr, Esik O, Bajzik G, Repa I, Dabasi G, Sinkovics I, et al. 18F-FDG PET detection of lymph node metastases in medullary thyroid carcinoma. J Nucl Med 2002; 43(1): 66-71. Available from: http://jnm.snmjournals. org/content/43/1/66.long [PubMed/ Google Scholar].
Salvatore B, Paone G, Klain M, Storto G, Nicolai E, D’Amico D, et al. Fluorodeoxyglucose PET/CT in patients with differentiated thyroid cancer and elevated thyroglobulin after total thyroidectomy and (131) I ablation. Q J Nucl Med Mol Imaging 2008; 52(1): 2-8. Available from: https://s3.amazonaws.com/academia. edu.documents/45342047/Fluorodeoxyglucose_ PETCT_in_patients_wit20160504-30608-k8z2qv. pdf?response-content-disposition=inline%3B%20 filename%3DFluorodeoxyglucose_PET_CT_in_ patients_wi.pdf&X-Amz-Algorithm=AWS4-HMACSHA256&X-Amz-Credential=AKIAIWOWYYGZ2Y53 UL3A%2F20200304%2Fus-east-1%2Fs3%2Faws4_ request&X-Amz-Date=20200304T102659Z&X-AmzExpires=3600&X-Amz-SignedHeaders=host&X-Amz-Si gnature=9e260f6375d8b9963f692c62ac2a20b4c16c3 4cbde11ac09b8c74d718e786dd1 [PubMed/ Google Scholar].
Li L, Chen BD, Zhu HF, Wu S, Wei D, Zhang JQ, et al. Comparison of Pre-operation Diagnosis of Thyroid Cancer with Fine Needle Aspiration and Coreneedle Biopsy: a Meta-analtsis. Asian Pac J Cancer Prev 2014; 15(17): 7187-7193. Available from: https://pdfs.semanticscholar.org/9347/e9d523f7c b98b141217b7708187b3813e11d.pdf [DOI: 10.7314/ APJCP.2014.15.17.7187/ PubMed/ Google Scholar].
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