Comparison of Liquid Based Cytology and Conventional Pap in Patients of Abnormal Vaginal Discharge Presenting with Pruritus Vulvae

Authors

  • Megha Kakkar Ex-Junior Resident, Department of Pathology, S.N. Medical College, Agra, Uttar Pradesh, India.
  • Pooja Agarwal "DEPARTMENT OF PATHOLOGY SN MEDICAL COLLEGE AGRA"
  • Tarun Mishra Assistant Professor, Department of Pathology, S.N. Medical College, Agra, Uttar Pradesh, India.
  • Divya Agrawal Junior Resident, Department of Pathology, S.N. Medical College, Agra, Uttar Pradesh, India.

Keywords:

Abnormal vaginal discharge, CP, LBC, Pruritus Vulvae

Abstract

Introduction: Vaginal discharge is one of the most common vaginal symptoms. Conditions causing vaginal discharge with pruritus vulvae are Candidiasis, Bacterial vaginosis and Trichomonas vaginalis. These can be diagnosed on cytology and confirmed by culture. This study was undertaken in patients to assess the efficacy of Liquid Based Cytology (LBC) and Conventional Pap (CP) and to know whether one of the methods has advantage over the other in cytologic diagnosis of infections.

Material and Methods: Paired samples for CP and LBC were collected from all the 40 patients of abnormal vaginal discharge presenting with pruritus vulvae. The smears were studied cytologically and sensitivity of each method was calculated Vaginals swabs were taken for culture.

Results: A total of 40 cases of abnormal vaginal discharge presenting with pruritus vulvae were studied. Total of 80% cases were in the reproductive age group (i.e. 20-50 years). LBC could diagnose 13 cases of bacterial vaginosis while CP diagnosed 14 cases with a sensitivity of 86.67% and 93.3% respectively. 6 cases were diagnosed cytologically as candidiasis by LBC and by 5 CP with a sensitivity of 75% and 62.5% respectively. LBC and CP both had a sensitivity of 50% in the detection of Trichomonas vaginalis.

Conclusion: Due to its cost effectiveness CP is as good as LBC in detection of specific infections especially in resource poor countries.

References

1. Paula J, Hillard A. Benign diseases of female reproductive tract. In: Berek JS (ed.) Berek and Novak’s Gynaecology. 14th ed. Wolters Kluwer, New Delhi. 2007. 489.
2. Padubidri VG, Daftary SN. Howkins and Bourne Shaw’s textbook of Gynaecology - Diseases of Vagina. 14th ed. 2008. 114.
3. Padubidri VG, Daftary SN. Howkins and Bourne Shaw’s textbook of Gynaecology - Diseases of Vulvae. 16th ed. 2015. 373.
4. Dutta DC. Sexually transmitted infections. In: Konar H (ed.) DC Dutta’s textbook of gynaecology. 6th ed. New central book agency, India. 2013. 146.
5. Dutta DC. Sexually transmitted infections. In: Konar H (ed.) DC Dutta’s textbook of gynaecology. 6th ed. New central book agency, India. 2013. 157-158.
6. Dutta DC. Sexually transmitted infections. In: Konar H (ed.) DC Dutta’s textbook of gynaecology. 6th ed. New central book agency, India. 2013. 159.
7. Sherwani RK, Khan T, Akhtar K et al. Conventional pap smear and liquid based cytology for cervical cancer screening - a comparative study. Journal of Cytology 2007; 24(4): 167-172.
8. Takei H, Ruiz B, Hicks J. Comparison of conventional pap smears and a liquid based thin-layer preparation. Am J Clin Pathol 2006; 125: 855-859. 9. Howell LP, Davis RL, Belk TI et al. The autocyte preparation system for gynecologic cytology. Acta Cytol 1998; 42: 171-177.
10. Cheung ANY, Szeto EF, Leung BSY et al. Liquid based cytology and conventional smears a comparison study in an Asian screening population. Cancer (Cancer Cytopathol) 2003; 99(6): 331-335.

Downloads

Published

2019-10-10

Issue

Vol. 5 No. 1 (2019): Recent Advances in Pathology & Laboratory Medicine

Section

Research Article

License

 

We, the undersigned, give an undertaking to the following effect with regard to our article entitled
“_______________________________________________________________________________________________________________________________________________________________________________
________________________________________________________________________________” submitted for publication in (Journal title)________________________________________________ _______________________________________________________Vol.________, Year _________:-

1. The article mentioned above has not been published or submitted to or accepted for publication in any form, in any other journal.

2. We also vouchsafe that the authorship of this article will not be contested by anyone whose name(s) is/are not listed by us here.

3. I/We declare that I/We contributed significantly towards the research study i.e., (a) conception, design and/or analysis and interpretation of data and to (b) drafting the article or revising it critically for important intellectual content and on (c) final approval of the version to be published.

4. I/We hereby acknowledge ADRs conflict of interest policy requirement to scrupulously avoid direct and indirect conflicts of interest and, accordingly, hereby agree to promptly inform the editor or editor's designee of any business, commercial, or other proprietary support, relationships, or interests that I/We may have which relate directly or indirectly to the subject of the work.

5. I/We also agree to the authorship of the article in the following sequence:-

Authors' Names (in sequence) Signature of Authors
1. _____________________________________ _____________________________________
2. _____________________________________ _____________________________________
3. _____________________________________ _____________________________________
4. _____________________________________ _____________________________________
5. _____________________________________ _____________________________________
6. _____________________________________ _____________________________________
7. _____________________________________ _____________________________________
8. _____________________________________ _____________________________________

Important

(I). All the authors are required to sign independently in this form in the sequence given above. In case an author has left the institution/ country and whose whereabouts are not known, the senior author may sign on his/ her behalf taking the responsibility.

(ii). No addition/ deletion/ or any change in the sequence of the authorship will be permissible at a later stage, without valid reasons and permission of the Editor.

(iii). If the authorship is contested at any stage, the article will be either returned or will not be
processed for publication till the issue is solved.