Large Cell Dysplasia and Its Relation to Liver Diseases
Abstract
Introduction: Large cell liver dysplasia is a premalignant hepatic lesion,
exhibiting abnormal nuclear characteristics like cellular enlargement,
nuclear polymorphism, hyperchromasia and multinucleation of
hepatocytes . There is no clear consensus relating LCD as the precursor
to Hepatocellular carcinoma; it results from oxidative stress.
Methods: Total of 8 liver biopsies were received from Department
of Pathology , Amrita School of Medicine, Faridabad . They were
microscopically reviewed over a period of 3 years for LCD, multiple
microscopic fields were examined for 1000 cells over 4-5 microscopic
fields at 40x .
Result: On observing the cases it was observed that LCD cases in
lymphoma were of a smaller age group, adenocarcinoma was of a
higher age group whereas hepatocellular carcinoma was of the highest
age group.Highest percentage of LCD was seen in cases of lymphoma
followed by adenocarcinoma and then hepatocellular carcinoma lowest
being in hepatitis.
Discussion: LCD is a combination of sustained liver injury , chronic
inflammation , oxidative stress, genetic and instability. Largest
percentage of LCD was seen in lymphoma cases which is a reactive
change .
The percentage of LCD in cases of adenocarcinoma was also high
due to indirect effects such as chemotherapy related liver damage ,
metastasis induced inflammation, cytokine release, oxidative stress
and malnutrition .The percentage of LCD is also increased in hepatitis
and hepatocellular carcinoma due to prolonged stress and damage
that chronic hepatitis inflicts on liver cells.
How to cite this article:
Maheshwari S, Modi K, Rana S, Mittal P. Large
Cell Dysplasia and Its Relation to Liver Diseases.
Rec Adv Path Lab Med. 2024;10(3&4):5-8.
References
Park YN, Roncalli M. Large liver cell dysplasia: a
controversial entity. J Hepatol. 2006;45(5):734-43.
[PubMed] [Google Scholar]
Anthony PP, Vogel CL, Barker LF. Liver cell dysplasia: a
premalignant condition. Journal of Clinical Pathology
;26:217-223.
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