Anti-Ulcer Activity of Methanolic Extract of Lagenaria Siceraria: A Review
Keywords:
Lagenaria siceraria, Anti-ulcer, Methanolic ExtractAbstract
Lagenaria siceraria, commonly known as bottle gourd, has been traditionally used in various cultures for its medicinal properties. One of its notable therapeutic potentials is its anti-ulcer activity, which has gained attention in recent research. This review aims to comprehensively analyze the scientific literature on the anti-ulcer properties of methanolic extracts derived from L. siceraria. It discusses the phytochemical composition, mechanisms of action, experimental models used for evaluation, and the overall therapeutic potential of L. siceraria in ulcer management.
How to cite this article:
Pikhwal S , Tyagi G. Anti-Ulcer Activity of
Methanolic Extract of Lagenaria Siceraria: A
Review. JAdv Res in medc che 2024; 6(1): 16-20.
References
Marshall BJ, Goodwin CS, Warren JR, Murray R, Blincow
ED, et al. (1988) Prospective double-blind trial of duo
denal ulcer relapse after eradication of Campylobacter
pylori. Lancet 2: 1437-1442.
Tytgat GNJ, Axon ATR, Dixon MF, Graham DY, Lee A,
et al. (1990) Helicobacter pylori: causal agent in peptic
ulcer disease? Working party reports of the 9th world
congress of gastroenterology, Sydney, Australia. Black
well Scientific Publications, New Jersey, USA.
Van Tongeren JHM (1984) Disappears peptic ulcer?
NedTijdschrgeneeskd 128: 510-513.
Hoogendoorn D (1984) Notable shifts in the epidemio
logical pattern of peptic ulcer. Ned Tijdschr Geneeskd
: 484-491.
Malfertheiner P, Leodolter A, Peitz U (2000) Cure of
Helicobacter pylori-associated ulcer disease through
eradication. Baillieres Best Pract Res Clin Gastroenterol
: 119-132
Howden CW, Hunt RH (1998) Guidelines for the man
agement of Helicobacter pylori infection. Ad Hoc
Committee on Practice Parameters of the American
College of Gastroenterology. Am J Gastroenterol 93:
-2338.
Mentis A, Lehours P, Mégraud F (2015) Epidemiology
and Diagnosis of Helicobacter pylori infection. Helico
bacter 20 Suppl 1: 1-7.
Liou JM, Chen CC, Lee YC, Chang CY, Wu JY, et al. (2016)
Systematic review with meta-analysis: 10- or 14-day
sequential therapy vs. 14- day triple therapy in the
f
irst line treatment of Helicobacter pylori infection.
Aliment Pharmacol Ther 43: 470-481.
Phadiya Anitakumari Rambhai,Sisodia S S (2018) Indian
Medicainal Plants for Treatment of Ulcer:Systematic
review.UK Journal of Pharmaceutical and Biosciences.
Vol. 6(6), 38-44.
Anti-ulcer activity of methanolic extract of Terminalia
chebula fruits in experimental rats. J. Pharm. Sci. &
Res. Vol.1 (3)101-107.
Habibur Rahaman A.S Bottle gourd -A vegitable for
good health,Natural product.
Kirtikar.k, Basu B.D (1999) Indian medical plant ,Vol.II In
ternational Book distributors,Dehradun,P.P.1116-1118.
Ram P.Rastogi, B.N. Mehotra,compendium of Indi
an medicinal plants,vol.4,1985-1989,central drug
research institute of science communication,New
Delhi,P.P.403-422.
Harbone,J.P. (1973) Phytochemical methods, a guide
to modern technique of plant analysis (chapmann and
hall London), P.P1-271.
Shay H, Komarov SA, Fele SS, Meranze D, Gruenstein H,
Siplet H.(1945)A simple method for uniform production
of gastric ulceration in rat, Gastroenterol, P.P43-61.
Kulkarni SK.(1999) Hand book of experimental phar
macology, Vallabh Prakashan, New Delhi,P.P 148-50.
Goel R.K, Govinda DasD, Sanyal,A.K, On changes in
duced by ulcerogenic agents on dissolved mucosub
stance in gastric juice.Indian Journal of Gastroenter
ology 4,249-251.
Gupta.M.B, Nath.R, Gupta.G.P, Bhargava.K.P, (1985) A
study of the antiulcer activity of diazepam and other
tranquillo sedatives in albino rats.clinical and experi
mental pharmacolgy12, 61-63.
Piper DW, Stiel DD.(1986) Pathogenesis of chronic
peptic ulcer DW, Stiel DD. Pathogenesis of chronic
peptic ulcer, current thinking and clinical implications.
Med Prog 2, 7-10
Dhuley JN. Protective effect of Rhinax, a herbal for
mation against physical and chemical factors induced
gastric and duodenal ulcers in rats. Indian J Pharmacol
, 31, 128-32
Soll AH. (1990) Pathogenesis of peptic ulcers and im
plication for therapy. New Eng J Med, 322, 909- 16.
Surendra S.(1999) Evaluation of gastric antiulcer activity
of fixed oil of tulsi and possible mechanism. Indian J
Exp Biol, 36(3), 253-57
